Abstract
The RNA interference (RNAi) method for targeted gene silencing is widely used in Caenorhabditis elegans for large-scale functional genomic studies, analysis of limited gene sets and detailed analysis of individual gene function. The application of RNAi has identified genes that participate in various aspects of development, physiology and cell biology. In addition, RNAi has been used to identify interacting genes and to study functionally redundant genes. This review discusses the various applications of RNAi in C. elegans, focusing particularly on the analysis of developmental processes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 184-194 |
| Number of pages | 11 |
| Journal | Briefings in Functional Genomics and Proteomics |
| Volume | 7 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 2008 |
Keywords
- Caenorhabditis elegans
- Functional genomics
- Gene interaction
- Gene networks
- RNA
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Genetics