Studying gene function in Caenorhabditis elegans using RNA-mediated interference

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

The RNA interference (RNAi) method for targeted gene silencing is widely used in Caenorhabditis elegans for large-scale functional genomic studies, analysis of limited gene sets and detailed analysis of individual gene function. The application of RNAi has identified genes that participate in various aspects of development, physiology and cell biology. In addition, RNAi has been used to identify interacting genes and to study functionally redundant genes. This review discusses the various applications of RNAi in C. elegans, focusing particularly on the analysis of developmental processes.

Original languageEnglish (US)
Pages (from-to)184-194
Number of pages11
JournalBriefings in Functional Genomics and Proteomics
Volume7
Issue number3
DOIs
StatePublished - May 2008

Keywords

  • Caenorhabditis elegans
  • Functional genomics
  • Gene interaction
  • Gene networks
  • RNA

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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