Studies toward the tricyclic core of phomactin A. Synthesis of the reduced furanochroman subunit

Punit P. Seth; Nancy I. Totah

doi:10.1021/ol0061788

Studies toward the tricyclic core of phomactin A. Synthesis of the reduced furanochroman subunit

Punit P. Seth, Nancy I. Totah

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Abstract

(equation presented) An approach to the tricyclic core of phomactin A is described via the synthesis of a reduced furanochroman model. Key elements of this study include the use of a highly functionalized 1-oxadecalone derivative as a template for the stereoselective introduction of functionality and a tandem retro aldol-epoxide opening-cyclization sequence for elaboration of the dihydrofuran ring.

Original language	English (US)
Pages (from-to)	2507-2509
Number of pages	3
Journal	Organic Letters
Volume	2
Issue number	16
DOIs	https://doi.org/10.1021/ol0061788
State	Published - Aug 10 2000
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol0061788

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title = "Studies toward the tricyclic core of phomactin A. Synthesis of the reduced furanochroman subunit",

abstract = "(equation presented) An approach to the tricyclic core of phomactin A is described via the synthesis of a reduced furanochroman model. Key elements of this study include the use of a highly functionalized 1-oxadecalone derivative as a template for the stereoselective introduction of functionality and a tandem retro aldol-epoxide opening-cyclization sequence for elaboration of the dihydrofuran ring.",

author = "Seth, {Punit P.} and Totah, {Nancy I.}",

year = "2000",

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doi = "10.1021/ol0061788",

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AU - Totah, Nancy I.

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N2 - (equation presented) An approach to the tricyclic core of phomactin A is described via the synthesis of a reduced furanochroman model. Key elements of this study include the use of a highly functionalized 1-oxadecalone derivative as a template for the stereoselective introduction of functionality and a tandem retro aldol-epoxide opening-cyclization sequence for elaboration of the dihydrofuran ring.

AB - (equation presented) An approach to the tricyclic core of phomactin A is described via the synthesis of a reduced furanochroman model. Key elements of this study include the use of a highly functionalized 1-oxadecalone derivative as a template for the stereoselective introduction of functionality and a tandem retro aldol-epoxide opening-cyclization sequence for elaboration of the dihydrofuran ring.

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Studies toward the tricyclic core of phomactin A. Synthesis of the reduced furanochroman subunit

Abstract

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