Studies toward the synthesis of phomactin A. An approach to the macrocyclic core

Dawei Teng; Bo Wang; Alex J. Augatis; Nancy I. Totah

doi:10.1016/j.tetlet.2007.04.122

Studies toward the synthesis of phomactin A. An approach to the macrocyclic core

Dawei Teng, Bo Wang, Alex J. Augatis, Nancy I. Totah

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27 Scopus citations

Abstract

An approach to the macrocyclic core of phomactin A is described. Central to this strategy is the use of a cis-fused oxadecalin intermediate, prepared using the dihydropyrone Diels-Alder reaction. The conformational bias inherent to this system is then used to facilitate macrocycle formation via an intramolecular B-alkyl Suzuki coupling.

Original language	English (US)
Pages (from-to)	4605-4607
Number of pages	3
Journal	Tetrahedron Letters
Volume	48
Issue number	26
DOIs	https://doi.org/10.1016/j.tetlet.2007.04.122
State	Published - Jun 25 2007

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2007.04.122

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title = "Studies toward the synthesis of phomactin A. An approach to the macrocyclic core",

abstract = "An approach to the macrocyclic core of phomactin A is described. Central to this strategy is the use of a cis-fused oxadecalin intermediate, prepared using the dihydropyrone Diels-Alder reaction. The conformational bias inherent to this system is then used to facilitate macrocycle formation via an intramolecular B-alkyl Suzuki coupling.",

author = "Dawei Teng and Bo Wang and Augatis, {Alex J.} and Totah, {Nancy I.}",

note = "Funding Information: Support from the National Institutes of Health, Institute of General Medical Sciences (R01 GM064357) is gratefully acknowledged. ",

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T1 - Studies toward the synthesis of phomactin A. An approach to the macrocyclic core

AU - Teng, Dawei

AU - Wang, Bo

AU - Augatis, Alex J.

AU - Totah, Nancy I.

N1 - Funding Information: Support from the National Institutes of Health, Institute of General Medical Sciences (R01 GM064357) is gratefully acknowledged.

PY - 2007/6/25

Y1 - 2007/6/25

N2 - An approach to the macrocyclic core of phomactin A is described. Central to this strategy is the use of a cis-fused oxadecalin intermediate, prepared using the dihydropyrone Diels-Alder reaction. The conformational bias inherent to this system is then used to facilitate macrocycle formation via an intramolecular B-alkyl Suzuki coupling.

AB - An approach to the macrocyclic core of phomactin A is described. Central to this strategy is the use of a cis-fused oxadecalin intermediate, prepared using the dihydropyrone Diels-Alder reaction. The conformational bias inherent to this system is then used to facilitate macrocycle formation via an intramolecular B-alkyl Suzuki coupling.

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U2 - 10.1016/j.tetlet.2007.04.122

DO - 10.1016/j.tetlet.2007.04.122

M3 - Article

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SN - 0040-4039

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EP - 4607

JO - Tetrahedron Letters

JF - Tetrahedron Letters

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ER -

Studies toward the synthesis of phomactin A. An approach to the macrocyclic core

Abstract

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