Studies toward the synthesis of phomactin A. An approach to the macrocyclic core

Dawei Teng, Bo Wang, Alex J. Augatis, Nancy Totah

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

An approach to the macrocyclic core of phomactin A is described. Central to this strategy is the use of a cis-fused oxadecalin intermediate, prepared using the dihydropyrone Diels-Alder reaction. The conformational bias inherent to this system is then used to facilitate macrocycle formation via an intramolecular B-alkyl Suzuki coupling.

Original languageEnglish (US)
Pages (from-to)4605-4607
Number of pages3
JournalTetrahedron Letters
Volume48
Issue number26
DOIs
StatePublished - Jun 25 2007

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Cycloaddition Reaction
phomactin A
oxadecalin

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Studies toward the synthesis of phomactin A. An approach to the macrocyclic core. / Teng, Dawei; Wang, Bo; Augatis, Alex J.; Totah, Nancy.

In: Tetrahedron Letters, Vol. 48, No. 26, 25.06.2007, p. 4605-4607.

Research output: Contribution to journalArticle

Teng, Dawei ; Wang, Bo ; Augatis, Alex J. ; Totah, Nancy. / Studies toward the synthesis of phomactin A. An approach to the macrocyclic core. In: Tetrahedron Letters. 2007 ; Vol. 48, No. 26. pp. 4605-4607.
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