Studies toward the synthesis of phomactin A. An approach to the macrocyclic core

Dawei Teng, Bo Wang, Alex J. Augatis, Nancy I. Totah

Research output: Contribution to journalArticle

24 Scopus citations


An approach to the macrocyclic core of phomactin A is described. Central to this strategy is the use of a cis-fused oxadecalin intermediate, prepared using the dihydropyrone Diels-Alder reaction. The conformational bias inherent to this system is then used to facilitate macrocycle formation via an intramolecular B-alkyl Suzuki coupling.

Original languageEnglish (US)
Pages (from-to)4605-4607
Number of pages3
JournalTetrahedron Letters
Issue number26
StatePublished - Jun 25 2007


ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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