An approach to the macrocyclic core of phomactin A is described. Central to this strategy is the use of a cis-fused oxadecalin intermediate, prepared using the dihydropyrone Diels-Alder reaction. The conformational bias inherent to this system is then used to facilitate macrocycle formation via an intramolecular B-alkyl Suzuki coupling.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Jun 25 2007|
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry