Studies on a model copper mono-oxygenase system: Peroxo-Cuii binuclear intermediates in the hydroxylation of an aromatic ring

Ninian J. Blackburn; Kenneth D. Karlin; Martin Concannon; Jon C. Hayes; Yilma Gultneh; Jon Zubieta

doi:10.1039/C39840000939

Studies on a model copper mono-oxygenase system: Peroxo-Cuⁱⁱ binuclear intermediates in the hydroxylation of an aromatic ring

Ninian J. Blackburn, Kenneth D. Karlin, Martin Concannon, Jon C. Hayes, Yilma Gultneh, Jon Zubieta

Research output: Contribution to journal › Article › peer-review

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Abstract

Hydrogen peroxide reacts with a Cuⁱⁱ complex of a m-xylyl binucleating ligand with concomitant hydroxylation to give a phenoxo-bridged complex (previously found as the product of the reaction of dioxygen with the Cuⁱ analogue) whereas a newly synthesized mononuclear analogue is unreactive, thereby implicating μ-peroxo-Cuⁱⁱ intermediates in the hydroxylation reaction.

Original language	English (US)
Pages (from-to)	939-940
Number of pages	2
Journal	Journal of the Chemical Society - Series Chemical Communications
Issue number	14
DOIs	https://doi.org/10.1039/C39840000939
State	Published - Jan 1 1984
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine

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title = "Studies on a model copper mono-oxygenase system: Peroxo-Cuii binuclear intermediates in the hydroxylation of an aromatic ring",

abstract = "Hydrogen peroxide reacts with a Cuii complex of a m-xylyl binucleating ligand with concomitant hydroxylation to give a phenoxo-bridged complex (previously found as the product of the reaction of dioxygen with the Cui analogue) whereas a newly synthesized mononuclear analogue is unreactive, thereby implicating μ-peroxo-Cuii intermediates in the hydroxylation reaction.",

author = "Blackburn, {Ninian J.} and Karlin, {Kenneth D.} and Martin Concannon and Hayes, {Jon C.} and Yilma Gultneh and Jon Zubieta",

year = "1984",

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doi = "10.1039/C39840000939",

language = "English (US)",

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T1 - Studies on a model copper mono-oxygenase system

T2 - Peroxo-Cuii binuclear intermediates in the hydroxylation of an aromatic ring

AU - Blackburn, Ninian J.

AU - Karlin, Kenneth D.

AU - Concannon, Martin

AU - Hayes, Jon C.

AU - Gultneh, Yilma

AU - Zubieta, Jon

PY - 1984/1/1

Y1 - 1984/1/1

N2 - Hydrogen peroxide reacts with a Cuii complex of a m-xylyl binucleating ligand with concomitant hydroxylation to give a phenoxo-bridged complex (previously found as the product of the reaction of dioxygen with the Cui analogue) whereas a newly synthesized mononuclear analogue is unreactive, thereby implicating μ-peroxo-Cuii intermediates in the hydroxylation reaction.

AB - Hydrogen peroxide reacts with a Cuii complex of a m-xylyl binucleating ligand with concomitant hydroxylation to give a phenoxo-bridged complex (previously found as the product of the reaction of dioxygen with the Cui analogue) whereas a newly synthesized mononuclear analogue is unreactive, thereby implicating μ-peroxo-Cuii intermediates in the hydroxylation reaction.

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DO - 10.1039/C39840000939

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Studies on a model copper mono-oxygenase system: Peroxo-Cuⁱⁱ binuclear intermediates in the hydroxylation of an aromatic ring

Abstract

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