Studies on a model copper mono-oxygenase system: Peroxo-CuII binuclear intermediates in the hydroxylation of an aromatic ring

Ninian J. Blackburn, Kenneth D. Karlin, Martin Concannon, Jon C. Hayes, Yilma Gultneh, Jon A Zubieta

Research output: Contribution to journalArticle

52 Scopus citations


Hydrogen peroxide reacts with a CuII complex of a m-xylyl binucleating ligand with concomitant hydroxylation to give a phenoxo-bridged complex (previously found as the product of the reaction of dioxygen with the CuI analogue) whereas a newly synthesized mononuclear analogue is unreactive, thereby implicating μ-peroxo-CuII intermediates in the hydroxylation reaction.

Original languageEnglish (US)
Pages (from-to)939-940
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number14
StatePublished - 1984
Externally publishedYes


ASJC Scopus subject areas

  • Molecular Medicine

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