Structural similarities within groups of pyridine nucleotide-linked dehydrogenases

Thomas P Fondy, Peter D. Holohan

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

If the pyridine nucleotide-linked dehydrogenases are related by evolution from one or a few common ancestral genes, it might be possible to suggest special evolutionary relationships among particular dehydrogenases by a comparison of structural and functional properties, even before extensive comparative primary sequence information is available. The dehydrogenases are compared using their amino acid compositions, isoelectric points, subunit molecular weights, and some functional properties. Amino acid compositions of dehydrogenases are tabulated per thousand total residues. The comparison of compositions is facilitated by using the difference index method developed by Metzger. The methods of comparison are evaluated using cytochromes c, proteases, and glyceraldehyde-3-phosphate dehydrogenases. Glutamate and glucose-6-phosphate dehydrogenases appear to be similar in many respects and mutually distinct from the other dehydrogenases. Similarities also appear to exist among the low molecular weight dehydrogenases: liver alcohol, mitochondrial malate, glycerol-3-phosphate, and NADP-linked isocitrate dehydrogenases. The Metzger difference index suggests that the primary sequence homology between H- and M-type lactic dehydrogenase subunits may be very extensive, perhaps being 75% identical.

Original languageEnglish (US)
Pages (from-to)229-244
Number of pages16
JournalJournal of Theoretical Biology
Volume31
Issue number2
DOIs
StatePublished - 1971

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pyridine nucleotides
Structural Similarity
Nucleotides
Phosphate
amino acid composition
Pyridine
functional properties
Oxidoreductases
molecular weight
isocitrate dehydrogenase
glyceraldehyde-3-phosphate dehydrogenase
Amino Acids
cytochrome c
glucose-6-phosphate 1-dehydrogenase
malates
isoelectric point
sequence homology
glutamates
glycerol
proteinases

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Structural similarities within groups of pyridine nucleotide-linked dehydrogenases. / Fondy, Thomas P; Holohan, Peter D.

In: Journal of Theoretical Biology, Vol. 31, No. 2, 1971, p. 229-244.

Research output: Contribution to journalArticle

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