Structural effects on persister control by brominated furanones

Jiachuan Pan; Dacheng Ren

doi:10.1016/j.bmcl.2013.10.070

Structural effects on persister control by brominated furanones

Jiachuan Pan, Dacheng Ren

Research output: Contribution to journal › Article

12 Scopus citations

Abstract

Bacterial persister cells are a small population of dormant cells that are tolerant to essentially all antibiotics. Recently, we reported that a quorum sensing (QS) inhibitor, (Z)-4-bromo-5-(bromomethylene)-3-methylfuran-2(5H)-one (BF8), can revert antibiotic tolerance of Pseudomonas aeruginosa persister cells. To better understand this phenomenon, several synthetic brominated furanones with similar structures were compared for their activities in persister control and inhibition of acyl-homoserine lactone (AHL) mediated QS. The results show that some other furanones in addition to BF8 are also AHL QS inhibitors and can revert antibiotic tolerance of P. aeruginosa PAO1 persister cells. However, not all QS inhibiting BFs can revert persistence at growth non-inhibitory concentrations, suggesting that QS inhibition itself is not sufficient for persister control.

Original language	English (US)
Pages (from-to)	6559-6562
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	23
Issue number	24
DOIs	https://doi.org/10.1016/j.bmcl.2013.10.070
State	Published - Dec 15 2013

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Keywords

Antibiotic tolerance
Brominated furanone
Persister
Pseudomonas aeruginosa
Quorum sensing
Structural effect

ASJC Scopus subject areas

Pharmaceutical Science
Drug Discovery
Organic Chemistry
Molecular Medicine
Molecular Biology
Clinical Biochemistry
Biochemistry

Cite this

Pan, J., & Ren, D. (2013). Structural effects on persister control by brominated furanones. Bioorganic and Medicinal Chemistry Letters, 23(24), 6559-6562. https://doi.org/10.1016/j.bmcl.2013.10.070

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abstract = "Bacterial persister cells are a small population of dormant cells that are tolerant to essentially all antibiotics. Recently, we reported that a quorum sensing (QS) inhibitor, (Z)-4-bromo-5-(bromomethylene)-3-methylfuran-2(5H)-one (BF8), can revert antibiotic tolerance of Pseudomonas aeruginosa persister cells. To better understand this phenomenon, several synthetic brominated furanones with similar structures were compared for their activities in persister control and inhibition of acyl-homoserine lactone (AHL) mediated QS. The results show that some other furanones in addition to BF8 are also AHL QS inhibitors and can revert antibiotic tolerance of P. aeruginosa PAO1 persister cells. However, not all QS inhibiting BFs can revert persistence at growth non-inhibitory concentrations, suggesting that QS inhibition itself is not sufficient for persister control.",

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Access to Document

10.1016/j.bmcl.2013.10.070