TY - JOUR
T1 - Structural effects on persister control by brominated furanones
AU - Pan, Jiachuan
AU - Ren, Dacheng
N1 - Funding Information:
We thank the U.S. National Science Foundation (CAREER-1055644 and EFRI-1137186) for partial support of this work. We are grateful to Professor Thomas K. Wood at Pennsylvania State University for sharing the strain of P. aeruginosa PAO1.
PY - 2013/12/15
Y1 - 2013/12/15
N2 - Bacterial persister cells are a small population of dormant cells that are tolerant to essentially all antibiotics. Recently, we reported that a quorum sensing (QS) inhibitor, (Z)-4-bromo-5-(bromomethylene)-3-methylfuran-2(5H)-one (BF8), can revert antibiotic tolerance of Pseudomonas aeruginosa persister cells. To better understand this phenomenon, several synthetic brominated furanones with similar structures were compared for their activities in persister control and inhibition of acyl-homoserine lactone (AHL) mediated QS. The results show that some other furanones in addition to BF8 are also AHL QS inhibitors and can revert antibiotic tolerance of P. aeruginosa PAO1 persister cells. However, not all QS inhibiting BFs can revert persistence at growth non-inhibitory concentrations, suggesting that QS inhibition itself is not sufficient for persister control.
AB - Bacterial persister cells are a small population of dormant cells that are tolerant to essentially all antibiotics. Recently, we reported that a quorum sensing (QS) inhibitor, (Z)-4-bromo-5-(bromomethylene)-3-methylfuran-2(5H)-one (BF8), can revert antibiotic tolerance of Pseudomonas aeruginosa persister cells. To better understand this phenomenon, several synthetic brominated furanones with similar structures were compared for their activities in persister control and inhibition of acyl-homoserine lactone (AHL) mediated QS. The results show that some other furanones in addition to BF8 are also AHL QS inhibitors and can revert antibiotic tolerance of P. aeruginosa PAO1 persister cells. However, not all QS inhibiting BFs can revert persistence at growth non-inhibitory concentrations, suggesting that QS inhibition itself is not sufficient for persister control.
KW - Antibiotic tolerance
KW - Brominated furanone
KW - Persister
KW - Pseudomonas aeruginosa
KW - Quorum sensing
KW - Structural effect
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U2 - 10.1016/j.bmcl.2013.10.070
DO - 10.1016/j.bmcl.2013.10.070
M3 - Article
C2 - 24268553
AN - SCOPUS:84888878771
VL - 23
SP - 6559
EP - 6562
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 24
ER -