Structural effects on persister control by brominated furanones

Jiachuan Pan; Dacheng Ren

doi:10.1016/j.bmcl.2013.10.070

Structural effects on persister control by brominated furanones

Jiachuan Pan, Dacheng Ren

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Bacterial persister cells are a small population of dormant cells that are tolerant to essentially all antibiotics. Recently, we reported that a quorum sensing (QS) inhibitor, (Z)-4-bromo-5-(bromomethylene)-3-methylfuran-2(5H)-one (BF8), can revert antibiotic tolerance of Pseudomonas aeruginosa persister cells. To better understand this phenomenon, several synthetic brominated furanones with similar structures were compared for their activities in persister control and inhibition of acyl-homoserine lactone (AHL) mediated QS. The results show that some other furanones in addition to BF8 are also AHL QS inhibitors and can revert antibiotic tolerance of P. aeruginosa PAO1 persister cells. However, not all QS inhibiting BFs can revert persistence at growth non-inhibitory concentrations, suggesting that QS inhibition itself is not sufficient for persister control.

Original language	English (US)
Pages (from-to)	6559-6562
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	23
Issue number	24
DOIs	https://doi.org/10.1016/j.bmcl.2013.10.070
State	Published - Dec 15 2013

Keywords

Antibiotic tolerance
Brominated furanone
Persister
Pseudomonas aeruginosa
Quorum sensing
Structural effect

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/j.bmcl.2013.10.070

Fingerprint Dive into the research topics of 'Structural effects on persister control by brominated furanones'. Together they form a unique fingerprint.

Cite this

@article{75267000de2b46c585812b9cd0d9fefa,

title = "Structural effects on persister control by brominated furanones",

abstract = "Bacterial persister cells are a small population of dormant cells that are tolerant to essentially all antibiotics. Recently, we reported that a quorum sensing (QS) inhibitor, (Z)-4-bromo-5-(bromomethylene)-3-methylfuran-2(5H)-one (BF8), can revert antibiotic tolerance of Pseudomonas aeruginosa persister cells. To better understand this phenomenon, several synthetic brominated furanones with similar structures were compared for their activities in persister control and inhibition of acyl-homoserine lactone (AHL) mediated QS. The results show that some other furanones in addition to BF8 are also AHL QS inhibitors and can revert antibiotic tolerance of P. aeruginosa PAO1 persister cells. However, not all QS inhibiting BFs can revert persistence at growth non-inhibitory concentrations, suggesting that QS inhibition itself is not sufficient for persister control.",

keywords = "Antibiotic tolerance, Brominated furanone, Persister, Pseudomonas aeruginosa, Quorum sensing, Structural effect",

author = "Jiachuan Pan and Dacheng Ren",

year = "2013",

month = dec,

day = "15",

doi = "10.1016/j.bmcl.2013.10.070",

language = "English (US)",

volume = "23",

pages = "6559--6562",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier",

number = "24",

}

TY - JOUR

T1 - Structural effects on persister control by brominated furanones

AU - Pan, Jiachuan

AU - Ren, Dacheng

PY - 2013/12/15

Y1 - 2013/12/15

N2 - Bacterial persister cells are a small population of dormant cells that are tolerant to essentially all antibiotics. Recently, we reported that a quorum sensing (QS) inhibitor, (Z)-4-bromo-5-(bromomethylene)-3-methylfuran-2(5H)-one (BF8), can revert antibiotic tolerance of Pseudomonas aeruginosa persister cells. To better understand this phenomenon, several synthetic brominated furanones with similar structures were compared for their activities in persister control and inhibition of acyl-homoserine lactone (AHL) mediated QS. The results show that some other furanones in addition to BF8 are also AHL QS inhibitors and can revert antibiotic tolerance of P. aeruginosa PAO1 persister cells. However, not all QS inhibiting BFs can revert persistence at growth non-inhibitory concentrations, suggesting that QS inhibition itself is not sufficient for persister control.

AB - Bacterial persister cells are a small population of dormant cells that are tolerant to essentially all antibiotics. Recently, we reported that a quorum sensing (QS) inhibitor, (Z)-4-bromo-5-(bromomethylene)-3-methylfuran-2(5H)-one (BF8), can revert antibiotic tolerance of Pseudomonas aeruginosa persister cells. To better understand this phenomenon, several synthetic brominated furanones with similar structures were compared for their activities in persister control and inhibition of acyl-homoserine lactone (AHL) mediated QS. The results show that some other furanones in addition to BF8 are also AHL QS inhibitors and can revert antibiotic tolerance of P. aeruginosa PAO1 persister cells. However, not all QS inhibiting BFs can revert persistence at growth non-inhibitory concentrations, suggesting that QS inhibition itself is not sufficient for persister control.

KW - Antibiotic tolerance

KW - Brominated furanone

KW - Persister

KW - Pseudomonas aeruginosa

KW - Quorum sensing

KW - Structural effect

UR - http://www.scopus.com/inward/record.url?scp=84888878771&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888878771&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2013.10.070

DO - 10.1016/j.bmcl.2013.10.070

M3 - Article

C2 - 24268553

AN - SCOPUS:84888878771

VL - 23

SP - 6559

EP - 6562

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 24

ER -