Stereochemistry of the succinic dehydrogenase system

O. Gawron, A. J. Glaid, Thomas P Fondy, M. M. Bechtold

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Abstract

IN continuation of work 1-3 on the stereochemistry of Krebs-cycle reactions, the stereochemistry of the succinic dehydrogenase reaction has been investigated with substrates that constrain the enzyme system to demonstrate its stereospecificity. These substrates are L-chlorosuccinic acid, newly found by us, and the L-enantiomorph of methylsuccinic acid; the racemic modification of the latter having been previously demonstrated 4,5 to decolorize methylene blue in the crude heart preparations.

Original languageEnglish (US)
Pages (from-to)1004-1005
Number of pages2
JournalNature
Volume189
Issue number4769
DOIs
StatePublished - 1961
Externally publishedYes

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Gawron, O., Glaid, A. J., Fondy, T. P., & Bechtold, M. M. (1961). Stereochemistry of the succinic dehydrogenase system. Nature, 189(4769), 1004-1005. https://doi.org/10.1038/1891004a0