Two different experimental paradigms were used to test a state-dependency explanation for memory impairments produced by convulsive doses (50 mg/kg i.p.) of Metrazol. The results using passive avoidance conditioning were suggestive but may have been confounded by the general activity depression that was found to follow Metrazol-induced seizures. In a discriminated escape paradigm the results were in agreement with predictions based on a state-dependency interpretation. These experiments suggest that Metrazol seizures, like electroconvulsive shock, may interfere with memory retrieval rather than storage.
- State-dependent learning
ASJC Scopus subject areas
- Experimental and Cognitive Psychology
- Behavioral Neuroscience