State-dependent learning produced by metrazol

Perry Kurtz, Tibor Palfai

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Two different experimental paradigms were used to test a state-dependency explanation for memory impairments produced by convulsive doses (50 mg/kg i.p.) of Metrazol. The results using passive avoidance conditioning were suggestive but may have been confounded by the general activity depression that was found to follow Metrazol-induced seizures. In a discriminated escape paradigm the results were in agreement with predictions based on a state-dependency interpretation. These experiments suggest that Metrazol seizures, like electroconvulsive shock, may interfere with memory retrieval rather than storage.

Original languageEnglish (US)
Pages (from-to)91-95
Number of pages5
JournalPhysiology and Behavior
Issue number1
StatePublished - Jan 1973


  • Amnesia
  • Dissociation
  • Memory
  • Metrazol
  • State-dependent learning

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

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