Specific maltose derivatives modulate the swarming motility of nonswarming mutant and inhibit bacterial adhesion and biofilm formation by pseudomonas aeruginosa

Gauri S. Shetye, Nischal Singh, Changqing Jia, Chan D K Nguyen, Guirong Wang, Yan Yeung Luk

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We have demonstrated that specific synthetic maltose derivatives activate the swarming motility of a Pseudomonas aeruginosa nonswarming mutant (rhlA) at low concentration, but inhibit it at high concentration. Although these molecules are not microbicidal, active maltose derivatives with bulky hydrocarbon groups inhibited bacterial adhesion, and exhibited biofilm inhibition and dispersion (IC50 ∼20 μM and DC50 ∼30 μM, respectively). Because the swarming motility of the rhlA mutant is abolished by the lack natural rhamnolipids, the swarming activation suggests that maltose derivatives are analogues of rhamnolipids. Together, these results suggest a new approach of controlling multiple bacterial activities (bacterial adhesion, biofilm formation, and swarming motility) by a set of disaccharide-based molecules.

Original languageEnglish (US)
Pages (from-to)1514-1523
Number of pages10
JournalChemBioChem
Volume15
Issue number10
DOIs
StatePublished - Jul 7 2014

Fingerprint

Bacterial Adhesion
Maltose
Biofilms
Pseudomonas aeruginosa
Adhesion
Derivatives
Molecules
Disaccharides
Hydrocarbons
Inhibitory Concentration 50
Chemical activation
rhamnolipid

Keywords

  • biofilm inhibition
  • disaccharide hydrocarbons
  • inhibitors
  • Pseudomonas aeruginosa
  • swarming motility

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Medicine(all)

Cite this

Specific maltose derivatives modulate the swarming motility of nonswarming mutant and inhibit bacterial adhesion and biofilm formation by pseudomonas aeruginosa. / Shetye, Gauri S.; Singh, Nischal; Jia, Changqing; Nguyen, Chan D K; Wang, Guirong; Luk, Yan Yeung.

In: ChemBioChem, Vol. 15, No. 10, 07.07.2014, p. 1514-1523.

Research output: Contribution to journalArticle

Shetye, Gauri S. ; Singh, Nischal ; Jia, Changqing ; Nguyen, Chan D K ; Wang, Guirong ; Luk, Yan Yeung. / Specific maltose derivatives modulate the swarming motility of nonswarming mutant and inhibit bacterial adhesion and biofilm formation by pseudomonas aeruginosa. In: ChemBioChem. 2014 ; Vol. 15, No. 10. pp. 1514-1523.
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AU - Luk, Yan Yeung

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