@article{76e41ce4e44147ec9e405072642e6632,
title = "Somatic aging pathways regulate reproductive plasticity in caenorhabditis elegans",
abstract = "In animals, early-life stress can result in programmed changes in gene expression that can affect their adult phenotype. In C. elegans nematodes, starvation during the first larval stage promotes entry into a stress-resistant dauer stage until environmental conditions improve. Adults that have experienced dauer (postdauers) retain a memory of early-life starvation that results in gene expression changes and reduced fecundity. Here, we show that the endocrine pathways attributed to the regulation of somatic aging in C. elegans adults lacking a functional germline also regulate the reproductive phenotypes of postdauer adults that experienced early-life starvation. We demonstrate that postdauer adults reallocate fat to benefit progeny at the expense of the parental somatic fat reservoir and exhibit increased longevity compared to controls. Our results also show that the modification of somatic fat stores due to parental starvation memory is inherited in the F1 generation and may be the result of crosstalk between somatic and reproductive tissues mediated by the germline nuclear RNAi pathway.",
author = "Ow, {Maria C.} and Nichitean, {Alexandra M.} and Hall, {Sarah E.}",
note = "Funding Information: We are grateful for the generous gift of dafachronic acid from Frank Schroeder and Pooja Gubi-banda for advice on its use. We thank Leszek Kotula and Angelina Regua for access to their micro-scope, Eleanor Maine for thoughtful comments on this manuscript, and Jason Fridley for assistance with statistics. Strains AA1052 and BS1080 were kindly provided by Adam Antebi and Tim Schedl, respectively. We thank the CGC, which is funded by the NIH Office of Research Infrastructure Programs (P40 OD010440), for providing strains. This work was partially supported by a NIH R01GM129135 grant to SEH. Funding Information: We are grateful for the generous gift of dafachronic acid from Frank Schroeder and Pooja Gubi-banda for advice on its use. We thank Leszek Kotula and Angelina Regua for access to their microscope, Eleanor Maine for thoughtful comments on this manuscript, and Jason Fridley for assistance with statistics. Strains AA1052 and BS1080 were kindly provided by Adam Antebi and Tim Schedl, respectively. We thank the CGC, which is funded by the NIH Office of Research Infrastructure Programs (P40 OD010440), for providing strains. This work was partially supported by a NIHR01GM129135 grant to SEH. Publisher Copyright: {\textcopyright} Ow et al.",
year = "2021",
doi = "10.7554/ELIFE.61459",
language = "English (US)",
volume = "10",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",
}