Abstract
How can dense biological tissue maintain sharp boundaries between coexisting cell populations? We explore this question within a simple vertex model for cells, focusing on the role of topology and tissue surface tension. We show that the ability of cells to independently regulate adhesivity and tension, together with neighbor-based interaction rules, lets them support strikingly unusual interfaces. In particular, we show that mechanical- and fluctuation-based measurements of the effective surface tension of a cellular aggregate yield different results, leading to mechanically soft interfaces that are nevertheless extremely sharp.
| Original language | English (US) |
|---|---|
| Article number | 058001 |
| Journal | Physical Review Letters |
| Volume | 120 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 29 2018 |
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ASJC Scopus subject areas
- Physics and Astronomy(all)
Cite this
Soft yet Sharp Interfaces in a Vertex Model of Confluent Tissue. / Sussman, Daniel M.; Schwarz, Jennifer M; Marchetti, M Cristina; Manning, Mary Elizabeth.
In: Physical Review Letters, Vol. 120, No. 5, 058001, 29.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Soft yet Sharp Interfaces in a Vertex Model of Confluent Tissue
AU - Sussman, Daniel M.
AU - Schwarz, Jennifer M
AU - Marchetti, M Cristina
AU - Manning, Mary Elizabeth
PY - 2018/1/29
Y1 - 2018/1/29
N2 - How can dense biological tissue maintain sharp boundaries between coexisting cell populations? We explore this question within a simple vertex model for cells, focusing on the role of topology and tissue surface tension. We show that the ability of cells to independently regulate adhesivity and tension, together with neighbor-based interaction rules, lets them support strikingly unusual interfaces. In particular, we show that mechanical- and fluctuation-based measurements of the effective surface tension of a cellular aggregate yield different results, leading to mechanically soft interfaces that are nevertheless extremely sharp.
AB - How can dense biological tissue maintain sharp boundaries between coexisting cell populations? We explore this question within a simple vertex model for cells, focusing on the role of topology and tissue surface tension. We show that the ability of cells to independently regulate adhesivity and tension, together with neighbor-based interaction rules, lets them support strikingly unusual interfaces. In particular, we show that mechanical- and fluctuation-based measurements of the effective surface tension of a cellular aggregate yield different results, leading to mechanically soft interfaces that are nevertheless extremely sharp.
UR - http://www.scopus.com/inward/record.url?scp=85041294281&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041294281&partnerID=8YFLogxK
U2 - 10.1103/PhysRevLett.120.058001
DO - 10.1103/PhysRevLett.120.058001
M3 - Article
C2 - 29481188
AN - SCOPUS:85041294281
VL - 120
JO - Physical Review Letters
JF - Physical Review Letters
SN - 0031-9007
IS - 5
M1 - 058001
ER -