TY - JOUR
T1 - Soft yet Sharp Interfaces in a Vertex Model of Confluent Tissue
AU - Sussman, Daniel M.
AU - Schwarz, J. M.
AU - Marchetti, M. Cristina
AU - Manning, M. Lisa
N1 - Funding Information:
This work was primarily supported by NSF-POLS-1607416. Additional support was provided by the Simons Foundation Targeted Grant No. 342354 (M. C. M.) and Investigator Grant No. 446222 (M. L. M.) in the Mathematical Modeling of Living Systems, the National Science Foundation Grants No. DMR-1609208 (M. C. M.), No. DMR-1507938 (J. M. S.), and No. DMR-1352184 (M. L. M.), and a Cottrell Scholar award from the Research Corporation for Science Advancement (M. L. M.). All authors acknowledge support of the Syracuse University Soft Matter Program and computing support through NSF ACI-1541396. The Tesla K40 used for this research was donated by the NVIDIA Corporation.
Publisher Copyright:
© 2018 American Physical Society.
PY - 2018/1/29
Y1 - 2018/1/29
N2 - How can dense biological tissue maintain sharp boundaries between coexisting cell populations? We explore this question within a simple vertex model for cells, focusing on the role of topology and tissue surface tension. We show that the ability of cells to independently regulate adhesivity and tension, together with neighbor-based interaction rules, lets them support strikingly unusual interfaces. In particular, we show that mechanical- and fluctuation-based measurements of the effective surface tension of a cellular aggregate yield different results, leading to mechanically soft interfaces that are nevertheless extremely sharp.
AB - How can dense biological tissue maintain sharp boundaries between coexisting cell populations? We explore this question within a simple vertex model for cells, focusing on the role of topology and tissue surface tension. We show that the ability of cells to independently regulate adhesivity and tension, together with neighbor-based interaction rules, lets them support strikingly unusual interfaces. In particular, we show that mechanical- and fluctuation-based measurements of the effective surface tension of a cellular aggregate yield different results, leading to mechanically soft interfaces that are nevertheless extremely sharp.
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U2 - 10.1103/PhysRevLett.120.058001
DO - 10.1103/PhysRevLett.120.058001
M3 - Article
C2 - 29481188
AN - SCOPUS:85041294281
VL - 120
JO - Physical Review Letters
JF - Physical Review Letters
SN - 0031-9007
IS - 5
M1 - 058001
ER -