@inproceedings{9bd09d8aab4444c996f3b783a137a9e3,
title = "Soft tissue small avascular tumor imaging with x-ray phase-contrast micro-CT in-line holography",
abstract = "To assess the feasibility of small soft tissue avascular tumor micro-CT imaging with x-ray phase-contrast in-line holography, we have studied micro-CT imaging with in-line geometry of small spheroidal avascular tumor models with quiescent cell core (< 250 μm) and various distributions of the proliferating cell density (PCD) forming the outer shell. We have simulated imaging with an ultrafast laser-based x-ray source with a Mo target. We observe phase-contrast enhancement of the tumor boundaries in the reconstructed transaxial images, resulting in improved detection of small soft tissue tumors, providing that the PCD density gradient is sufficiently large.",
keywords = "Micro-CT imaging, Soft tissue avascular tumor model, Tumor detection, X-ray phase-contrast in in-line holography",
author = "Yakov Nesterets and Tim Gureyev and Andrew Stevenson and Andrew Pogany and Steve Wilkins and Russell Kincaid and Hongwei Ye and Levon Vogelsang and Edward Lipson and Ioana Coman and Sylvain Fourmaux and Kieffer, {Jean Claude} and Andrzej Krol",
year = "2008",
doi = "10.1117/12.772761",
language = "English (US)",
isbn = "9780819470973",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Medical Imaging 2008 - Physics of Medical Imaging",
note = "Medical Imaging 2008 - Physics of Medical Imaging ; Conference date: 18-02-2008 Through 21-02-2008",
}