Soft tissue small avascular tumor imaging with x-ray phase-contrast micro-CT in-line holography

Yakov Nesterets, Tim Gureyev, Andrew Stevenson, Andrew Pogany, Steve Wilkins, Russell Kincaid, Hongwei Ye, Levon Vogelsang, Edward Lipson, Ioana Coman, Sylvain Fourmaux, Jean Claude Kieffer, Andrzej Krol

Research output: Chapter in Book/Report/Conference proceedingConference contribution

11 Scopus citations


To assess the feasibility of small soft tissue avascular tumor micro-CT imaging with x-ray phase-contrast in-line holography, we have studied micro-CT imaging with in-line geometry of small spheroidal avascular tumor models with quiescent cell core (< 250 μm) and various distributions of the proliferating cell density (PCD) forming the outer shell. We have simulated imaging with an ultrafast laser-based x-ray source with a Mo target. We observe phase-contrast enhancement of the tumor boundaries in the reconstructed transaxial images, resulting in improved detection of small soft tissue tumors, providing that the PCD density gradient is sufficiently large.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2008 - Physics of Medical Imaging
StatePublished - 2008
EventMedical Imaging 2008 - Physics of Medical Imaging - San Diego, CA, United States
Duration: Feb 18 2008Feb 21 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMedical Imaging 2008 - Physics of Medical Imaging
Country/TerritoryUnited States
CitySan Diego, CA


  • Micro-CT imaging
  • Soft tissue avascular tumor model
  • Tumor detection
  • X-ray phase-contrast in in-line holography

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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