Soft tissue small avascular tumor imaging with x-ray phase-contrast micro-CT in-line holography

Yakov Nesterets, Tim Gureyev, Andrew Stevenson, Andrew Pogany, Steve Wilkins, Russell Kincaid, Hongwei Ye, Levon Vogelsang, Edward Lipson, Ioana Coman, Sylvain Fourmaux, Jean Claude Kieffer, Andrzej Krol

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

To assess the feasibility of small soft tissue avascular tumor micro-CT imaging with x-ray phase-contrast in-line holography, we have studied micro-CT imaging with in-line geometry of small spheroidal avascular tumor models with quiescent cell core (< 250 μm) and various distributions of the proliferating cell density (PCD) forming the outer shell. We have simulated imaging with an ultrafast laser-based x-ray source with a Mo target. We observe phase-contrast enhancement of the tumor boundaries in the reconstructed transaxial images, resulting in improved detection of small soft tissue tumors, providing that the PCD density gradient is sufficiently large.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6913
DOIs
StatePublished - 2008
EventMedical Imaging 2008 - Physics of Medical Imaging - San Diego, CA, United States
Duration: Feb 18 2008Feb 21 2008

Other

OtherMedical Imaging 2008 - Physics of Medical Imaging
CountryUnited States
CitySan Diego, CA
Period2/18/082/21/08

Fingerprint

Holography
Tumors
Tissue
Imaging techniques
X rays
Ultrafast lasers
Geometry

Keywords

  • Micro-CT imaging
  • Soft tissue avascular tumor model
  • Tumor detection
  • X-ray phase-contrast in in-line holography

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Nesterets, Y., Gureyev, T., Stevenson, A., Pogany, A., Wilkins, S., Kincaid, R., ... Krol, A. (2008). Soft tissue small avascular tumor imaging with x-ray phase-contrast micro-CT in-line holography. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 6913). [69133Z] https://doi.org/10.1117/12.772761

Soft tissue small avascular tumor imaging with x-ray phase-contrast micro-CT in-line holography. / Nesterets, Yakov; Gureyev, Tim; Stevenson, Andrew; Pogany, Andrew; Wilkins, Steve; Kincaid, Russell; Ye, Hongwei; Vogelsang, Levon; Lipson, Edward; Coman, Ioana; Fourmaux, Sylvain; Kieffer, Jean Claude; Krol, Andrzej.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6913 2008. 69133Z.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nesterets, Y, Gureyev, T, Stevenson, A, Pogany, A, Wilkins, S, Kincaid, R, Ye, H, Vogelsang, L, Lipson, E, Coman, I, Fourmaux, S, Kieffer, JC & Krol, A 2008, Soft tissue small avascular tumor imaging with x-ray phase-contrast micro-CT in-line holography. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 6913, 69133Z, Medical Imaging 2008 - Physics of Medical Imaging, San Diego, CA, United States, 2/18/08. https://doi.org/10.1117/12.772761
Nesterets Y, Gureyev T, Stevenson A, Pogany A, Wilkins S, Kincaid R et al. Soft tissue small avascular tumor imaging with x-ray phase-contrast micro-CT in-line holography. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6913. 2008. 69133Z https://doi.org/10.1117/12.772761
Nesterets, Yakov ; Gureyev, Tim ; Stevenson, Andrew ; Pogany, Andrew ; Wilkins, Steve ; Kincaid, Russell ; Ye, Hongwei ; Vogelsang, Levon ; Lipson, Edward ; Coman, Ioana ; Fourmaux, Sylvain ; Kieffer, Jean Claude ; Krol, Andrzej. / Soft tissue small avascular tumor imaging with x-ray phase-contrast micro-CT in-line holography. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6913 2008.
@inproceedings{9bd09d8aab4444c996f3b783a137a9e3,
title = "Soft tissue small avascular tumor imaging with x-ray phase-contrast micro-CT in-line holography",
abstract = "To assess the feasibility of small soft tissue avascular tumor micro-CT imaging with x-ray phase-contrast in-line holography, we have studied micro-CT imaging with in-line geometry of small spheroidal avascular tumor models with quiescent cell core (< 250 μm) and various distributions of the proliferating cell density (PCD) forming the outer shell. We have simulated imaging with an ultrafast laser-based x-ray source with a Mo target. We observe phase-contrast enhancement of the tumor boundaries in the reconstructed transaxial images, resulting in improved detection of small soft tissue tumors, providing that the PCD density gradient is sufficiently large.",
keywords = "Micro-CT imaging, Soft tissue avascular tumor model, Tumor detection, X-ray phase-contrast in in-line holography",
author = "Yakov Nesterets and Tim Gureyev and Andrew Stevenson and Andrew Pogany and Steve Wilkins and Russell Kincaid and Hongwei Ye and Levon Vogelsang and Edward Lipson and Ioana Coman and Sylvain Fourmaux and Kieffer, {Jean Claude} and Andrzej Krol",
year = "2008",
doi = "10.1117/12.772761",
language = "English (US)",
isbn = "9780819470973",
volume = "6913",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

}

TY - GEN

T1 - Soft tissue small avascular tumor imaging with x-ray phase-contrast micro-CT in-line holography

AU - Nesterets, Yakov

AU - Gureyev, Tim

AU - Stevenson, Andrew

AU - Pogany, Andrew

AU - Wilkins, Steve

AU - Kincaid, Russell

AU - Ye, Hongwei

AU - Vogelsang, Levon

AU - Lipson, Edward

AU - Coman, Ioana

AU - Fourmaux, Sylvain

AU - Kieffer, Jean Claude

AU - Krol, Andrzej

PY - 2008

Y1 - 2008

N2 - To assess the feasibility of small soft tissue avascular tumor micro-CT imaging with x-ray phase-contrast in-line holography, we have studied micro-CT imaging with in-line geometry of small spheroidal avascular tumor models with quiescent cell core (< 250 μm) and various distributions of the proliferating cell density (PCD) forming the outer shell. We have simulated imaging with an ultrafast laser-based x-ray source with a Mo target. We observe phase-contrast enhancement of the tumor boundaries in the reconstructed transaxial images, resulting in improved detection of small soft tissue tumors, providing that the PCD density gradient is sufficiently large.

AB - To assess the feasibility of small soft tissue avascular tumor micro-CT imaging with x-ray phase-contrast in-line holography, we have studied micro-CT imaging with in-line geometry of small spheroidal avascular tumor models with quiescent cell core (< 250 μm) and various distributions of the proliferating cell density (PCD) forming the outer shell. We have simulated imaging with an ultrafast laser-based x-ray source with a Mo target. We observe phase-contrast enhancement of the tumor boundaries in the reconstructed transaxial images, resulting in improved detection of small soft tissue tumors, providing that the PCD density gradient is sufficiently large.

KW - Micro-CT imaging

KW - Soft tissue avascular tumor model

KW - Tumor detection

KW - X-ray phase-contrast in in-line holography

UR - http://www.scopus.com/inward/record.url?scp=43149092944&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=43149092944&partnerID=8YFLogxK

U2 - 10.1117/12.772761

DO - 10.1117/12.772761

M3 - Conference contribution

AN - SCOPUS:43149092944

SN - 9780819470973

VL - 6913

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

ER -