Small molecule targeting of SHIP1 and SHIP2

William G. Kerr, Chiara Pedicone, Shawn Dormann, Angela Pacherille, John D. Chisholm

Research output: Contribution to journalReview article

Abstract

Modulating the activity of the Src Homology 2 (SH2) - containing Inositol 5'- Phosphatase (SHIP) enzyme family with small molecule inhibitors provides a useful and unconventional method of influencing cell signaling in the PI3K pathway. The development of small molecules that selectively target one of the SHIP paralogs (SHIP1 or SHIP2) as well as inhibitors that simultaneously target both enzymes have provided promising data linking the phosphatase activity of the SHIP enzymes to disorders and disease states that are in dire need of new therapeutic targets. These include cancer, immunotherapy, diabetes, obesity, and Alzheimer's disease. In this mini-review, we will provide a brief overview of research in these areas that support targeting SHIP1, SHIP2 or both enzymes for therapeutic purposes.

Original languageEnglish (US)
Pages (from-to)291-300
Number of pages10
JournalBiochemical Society transactions
Volume48
Issue number1
DOIs
StatePublished - 2020

ASJC Scopus subject areas

  • Biochemistry

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