@article{60f98854295044ef9bdb9c5257c11d16,
title = "Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants",
abstract = "Adjuvants are added to vaccines to enhance the immune response and provide increased protection against disease. In the last decade, hundreds of synthetic immune adjuvants have been created, but many induce undesirable levels of proinflammatory cytokines including TNF-α and IL-6. Here we present small molecule NF-κB inhibitors that can be used in combination with an immune adjuvant to both decrease markers associated with poor tolerability and improve the protective response of vaccination. Additionally, we synthesize a library of honokiol derivatives identifying several promising candidates for use in vaccine formulations.",
keywords = "NF-κB, adjuvants, capsaicin, honokiol, vaccines",
author = "Moser, {Brittany A.} and Yoseline Escalante-Buendia and Steinhardt, {Rachel C.} and Rosenberger, {Matthew G.} and Cassaidy, {Britteny J.} and Nihesh Naorem and Chon, {Alfred C.} and Nguyen, {Minh H.} and Tran, {Ngoctran T.} and Esser-Kahn, {Aaron P.}",
note = "Funding Information: Funding. We would like to acknowledge support by the NIH (1U01Al124286-01 and 1DP2Al112194-01, GM099594). AE-K thanks the Pew Scholars Program and the Cottrell Scholars Program for generous support. BM thanks NSF-GRFP (DGE-1321846). BC thanks NSF-GRFP (DGE-1746045). We would also like to thank NSF instrumentation grant CHE-1048528. This work was supported, in part, by a grant from the Alfred P. Sloan Foundation. Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2020 Moser, Escalante-Buendia, Steinhardt, Rosenberger, Cassaidy, Naorem, Chon, Nguyen, Tran and Esser-Kahn.",
year = "2020",
month = sep,
day = "25",
doi = "10.3389/fimmu.2020.511513",
language = "English (US)",
volume = "11",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media S. A.",
}