Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants

Brittany A. Moser; Yoseline Escalante-Buendia; Rachel C. Steinhardt; Matthew G. Rosenberger; Britteny J. Cassaidy; Nihesh Naorem; Alfred C. Chon; Minh H. Nguyen; Ngoctran T. Tran; Aaron P. Esser-Kahn

doi:10.3389/fimmu.2020.511513

Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants

Brittany A. Moser, Yoseline Escalante-Buendia, Rachel C. Steinhardt, Matthew G. Rosenberger, Britteny J. Cassaidy, Nihesh Naorem, Alfred C. Chon, Minh H. Nguyen, Ngoctran T. Tran, Aaron P. Esser-Kahn

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Adjuvants are added to vaccines to enhance the immune response and provide increased protection against disease. In the last decade, hundreds of synthetic immune adjuvants have been created, but many induce undesirable levels of proinflammatory cytokines including TNF-α and IL-6. Here we present small molecule NF-κB inhibitors that can be used in combination with an immune adjuvant to both decrease markers associated with poor tolerability and improve the protective response of vaccination. Additionally, we synthesize a library of honokiol derivatives identifying several promising candidates for use in vaccine formulations.

Original language	English (US)
Article number	511513
Journal	Frontiers in Immunology
Volume	11
DOIs	https://doi.org/10.3389/fimmu.2020.511513
State	Published - Sep 25 2020
Externally published	Yes

Keywords

NF-κB
adjuvants
capsaicin
honokiol
vaccines

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.3389/fimmu.2020.511513

Cite this

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title = "Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants",

abstract = "Adjuvants are added to vaccines to enhance the immune response and provide increased protection against disease. In the last decade, hundreds of synthetic immune adjuvants have been created, but many induce undesirable levels of proinflammatory cytokines including TNF-α and IL-6. Here we present small molecule NF-κB inhibitors that can be used in combination with an immune adjuvant to both decrease markers associated with poor tolerability and improve the protective response of vaccination. Additionally, we synthesize a library of honokiol derivatives identifying several promising candidates for use in vaccine formulations.",

keywords = "NF-κB, adjuvants, capsaicin, honokiol, vaccines",

author = "Moser, {Brittany A.} and Yoseline Escalante-Buendia and Steinhardt, {Rachel C.} and Rosenberger, {Matthew G.} and Cassaidy, {Britteny J.} and Nihesh Naorem and Chon, {Alfred C.} and Nguyen, {Minh H.} and Tran, {Ngoctran T.} and Esser-Kahn, {Aaron P.}",

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year = "2020",

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doi = "10.3389/fimmu.2020.511513",

language = "English (US)",

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AU - Moser, Brittany A.

AU - Escalante-Buendia, Yoseline

AU - Steinhardt, Rachel C.

AU - Rosenberger, Matthew G.

AU - Cassaidy, Britteny J.

AU - Naorem, Nihesh

AU - Chon, Alfred C.

AU - Nguyen, Minh H.

AU - Tran, Ngoctran T.

AU - Esser-Kahn, Aaron P.

PY - 2020/9/25

Y1 - 2020/9/25

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AB - Adjuvants are added to vaccines to enhance the immune response and provide increased protection against disease. In the last decade, hundreds of synthetic immune adjuvants have been created, but many induce undesirable levels of proinflammatory cytokines including TNF-α and IL-6. Here we present small molecule NF-κB inhibitors that can be used in combination with an immune adjuvant to both decrease markers associated with poor tolerability and improve the protective response of vaccination. Additionally, we synthesize a library of honokiol derivatives identifying several promising candidates for use in vaccine formulations.

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Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants

Abstract

Keywords

ASJC Scopus subject areas

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