Sleep and memory relationships in intact old and amnestic young rats

William S. Stone, Paul E. Gold

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


Age-related changes in sleep are observed in many species, including rats and humans. Old rats often exhibit less total and paradoxical sleep, shorter sleep bouts and more random sleep-wake periods across 24 hours, than young rats. This paper evaluates recent evidence that deterioration of selected sleep parameters, usually involving levels of paradoxical sleep or durations of sleep bouts, may be related to deterioration of memory in old rats. Similar findings are reviewed with respect to young animals with different forms of experimentally-induced amnesia. Furthermore, a drug that enhances memory in rats and old humans, glucose, also enhances paradoxical sleep in old rats. These data suggest the utility of sleep measures as neurobiological markers of memory dysfunction in old rats.

Original languageEnglish (US)
Pages (from-to)719-727
Number of pages9
JournalNeurobiology of Aging
Issue numberC
StatePublished - 1988
Externally publishedYes


  • Aging
  • Memory
  • Paradoxical sleep
  • Rats
  • Sleep

ASJC Scopus subject areas

  • General Neuroscience
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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