Abstract
Reaction of vitamin B12 (B12) with excess 2-iodoxybenzoic acid and 2-hydroxypyridine leads to selective oxidation of the 5'-hydroxyl group of the ribose tail of B12 in a 30% isolated yield. The acid derivative was purified in one step by HPLC chromatography and characterized by MALDI-TOF mass spectrometry, 1H NMR and 2D (HSQC and HMBC) NMR. The new carboxylic acid derivative is perfectly suited to make stable amide-based B12 bioconjugates.
Original language | English (US) |
---|---|
Article number | ST-2012-R0524-L |
Pages (from-to) | 2363-2366 |
Number of pages | 4 |
Journal | Synlett |
Volume | 23 |
Issue number | 16 |
DOIs | |
State | Published - 2012 |
Keywords
- 2-iodoxybenzoic acid
- Carboxylic acids
- Cobalamin
- Oxidation
- Vitamins
ASJC Scopus subject areas
- Organic Chemistry