Site directed maleimide bifunctional chelators for the M(CO) 3+ core (M = 99mTc, Re)

Sangeeta Ray Banerjee; John W. Babich; Jon Zubieta

doi:10.1039/b417588c

Site directed maleimide bifunctional chelators for the M(CO) ₃⁺ core (M = ^99mTc, Re)

Sangeeta Ray Banerjee, John W. Babich, Jon Zubieta

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

A series of bifunctional chelates containing a tridentate donor set for complexation of the M(CO)₃⁺ core and a maleimide group for site-specific coupling to peptides and proteins containing free thiol groups has been prepared and their Re(CO)₃⁺ complexes and glutathione conjugates structurally characterized. The flexibility of design allows preparation of ligands suitable for both fluorescence imaging, radioimaging and radiotherapeutic studies of proteins and peptides as well as other biopolymers using site specific conjugation.

Original language	English (US)
Pages (from-to)	1784-1786
Number of pages	3
Journal	Chemical Communications
Issue number	13
DOIs	https://doi.org/10.1039/b417588c
State	Published - Apr 7 2005

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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10.1039/b417588c

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Site directed maleimide bifunctional chelators for the M(CO) ₃⁺ core (M = ^99mTc, Re)

Abstract

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