Single lipid diffusion in Langmuir monolayers

Martin B. Forstner, Josef Käs, Douglas Martin

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Individual lipid movement in a monolayer is studied over long time intervals (500 s) by darkfield microscopy of single lipids labeled with gold colloids (30 or 100 nm in diameter). Dimyristoyl phosphatidylcholine in the fluid phase shows normal diffusion, with a diffusion coefficient of (1.1±0.2)×10-8 cm2/s. Since this is consistent with values derived from the diffusive transport of many lipids, the analysis of gold-tagged lipids in a monolayer provides a reliable picture of lipid diffusion on the level of single molecules.

Original languageEnglish (US)
Pages (from-to)567-570
Number of pages4
Issue number3
StatePublished - Feb 6 2001

ASJC Scopus subject areas

  • General Materials Science
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry


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