Single lipid diffusion in Langmuir monolayers

Martin B. Forstner; Josef Käs; Douglas Martin

doi:10.1021/la000795n

Single lipid diffusion in Langmuir monolayers

Martin B. Forstner, Josef Käs, Douglas Martin

Department of Physics

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Individual lipid movement in a monolayer is studied over long time intervals (500 s) by darkfield microscopy of single lipids labeled with gold colloids (30 or 100 nm in diameter). Dimyristoyl phosphatidylcholine in the fluid phase shows normal diffusion, with a diffusion coefficient of (1.1±0.2)×10^-8 cm²/s. Since this is consistent with values derived from the diffusive transport of many lipids, the analysis of gold-tagged lipids in a monolayer provides a reliable picture of lipid diffusion on the level of single molecules.

Original language	English (US)
Pages (from-to)	567-570
Number of pages	4
Journal	Langmuir
Volume	17
Issue number	3
DOIs	https://doi.org/10.1021/la000795n
State	Published - Feb 6 2001

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics
Surfaces and Interfaces
Spectroscopy
Electrochemistry

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AB - Individual lipid movement in a monolayer is studied over long time intervals (500 s) by darkfield microscopy of single lipids labeled with gold colloids (30 or 100 nm in diameter). Dimyristoyl phosphatidylcholine in the fluid phase shows normal diffusion, with a diffusion coefficient of (1.1±0.2)×10-8 cm2/s. Since this is consistent with values derived from the diffusive transport of many lipids, the analysis of gold-tagged lipids in a monolayer provides a reliable picture of lipid diffusion on the level of single molecules.

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Single lipid diffusion in Langmuir monolayers

Abstract

ASJC Scopus subject areas

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