Single amino acid chelate complexes of the M(CO)3 + core for correlating fluorescence and radioimaging studies (M = 99mTc or Re)

Michael P. Coogan, Robert Patrick Doyle, John F. Valliant, John W. Babich, Jon A Zubieta

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Single amino acid chelates (SAACs) and SAAC-like bifunctional ligands can be exploited in the design of a variety of bioconjugates for facile metallation with the M(CO)3 + unit with M = 99mTc or Re. When the donor groups of the ligand are quinolone, thiazole or other similarly conjugated heterocycles, the rhenium complexes are fluorescent, affording complementary and isostructural fluorescent probes to the radioactive 99mTc analogues. The versatility of the approach has been demonstrated by the preparation of bioconjugates incorporating peptides, biotin, folic acid, thymidine and vitamin B12. In addition, the unusual photophysical properties observed for rhenium of the [bisthiazole-diamino butane-Re(CO)3 +] derivative [BTBA-Re(CO)3] + are discussed.

Original languageEnglish (US)
Pages (from-to)255-261
Number of pages7
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume57
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Carbon Monoxide
Rhenium
Fluorescence
Amino Acids
Ligands
Thiazoles
Quinolones
Vitamin B 12
Biotin
Fluorescent Dyes
Folic Acid
Thymidine
Derivatives
Peptides

Keywords

  • bioconjugate chemistry
  • correlation of in vitro fluorescence and in vivo radioimaging
  • fluorescence spectroscopy
  • rhenium photophysics
  • rhenium-tricarbonyl core

ASJC Scopus subject areas

  • Analytical Chemistry
  • Organic Chemistry
  • Spectroscopy
  • Drug Discovery
  • Radiology Nuclear Medicine and imaging
  • Biochemistry
  • Medicine(all)

Cite this

Single amino acid chelate complexes of the M(CO)3 + core for correlating fluorescence and radioimaging studies (M = 99mTc or Re). / Coogan, Michael P.; Doyle, Robert Patrick; Valliant, John F.; Babich, John W.; Zubieta, Jon A.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 57, No. 4, 2014, p. 255-261.

Research output: Contribution to journalArticle

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AU - Babich, John W.

AU - Zubieta, Jon A

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