TY - GEN
T1 - Simultaneous, noninvasive, in vivo, continuous monitoring of hematocrit, vascular volume, hemoglobin oxygen saturation, pulse rate and breathing rate in humans and other animal models using a single light source
AU - Dent, Paul
AU - Tun, Sai Han
AU - Fillioe, Seth
AU - Deng, Bin
AU - Satalin, Josh
AU - Nieman, Gary
AU - Wilcox, Kailyn
AU - Searles, Quinn
AU - Narsipur, Sri
AU - Peterson, Charles M.
AU - Goodisman, Jerry
AU - Mostrom, James
AU - Steinmann, Richard
AU - Chaiken, J.
N1 - Publisher Copyright:
© 2018 SPIE.
PY - 2018
Y1 - 2018
N2 - We previously reported a new algorithm "PV[O]H" for continuous, noninvasive, in vivo monitoring of hematocrit changes in blood and have since shown its utility for monitoring in humans during 1) hemodialysis, 2) orthostatic perturbations and 3) during blood loss and fluid replacement in a rat model. We now show that the algorithm is sensitive to changes in hemoglobin oxygen saturation. We document the phenomenology of the effect and explain the effect using new results obtained from humans and rat models. The oxygen sensitivity derives from the differential absorption of autofluorescence originating in the static tissues by oxy and deoxy hemoglobin. Using this approach we show how to perform simultaneous, noninvasive, in vivo, continuous monitoring of hematocrit, vascular volume, hemoglobin oxygen saturation, pulse rate and breathing rate in mammals using a single light source. We suspect that monitoring of changes in this suite of vital signs can be provided with improved time response, sensitivity and precision compared to existing methodologies. Initial results also offer a more detailed glimpse into the systemic oxygen transport in the circulatory system of humans.
AB - We previously reported a new algorithm "PV[O]H" for continuous, noninvasive, in vivo monitoring of hematocrit changes in blood and have since shown its utility for monitoring in humans during 1) hemodialysis, 2) orthostatic perturbations and 3) during blood loss and fluid replacement in a rat model. We now show that the algorithm is sensitive to changes in hemoglobin oxygen saturation. We document the phenomenology of the effect and explain the effect using new results obtained from humans and rat models. The oxygen sensitivity derives from the differential absorption of autofluorescence originating in the static tissues by oxy and deoxy hemoglobin. Using this approach we show how to perform simultaneous, noninvasive, in vivo, continuous monitoring of hematocrit, vascular volume, hemoglobin oxygen saturation, pulse rate and breathing rate in mammals using a single light source. We suspect that monitoring of changes in this suite of vital signs can be provided with improved time response, sensitivity and precision compared to existing methodologies. Initial results also offer a more detailed glimpse into the systemic oxygen transport in the circulatory system of humans.
KW - Hematocrit
KW - SPO2
KW - breathing rate
KW - continuous
KW - noninvasive
KW - vascular volume
KW - vital sign monitoring
UR - http://www.scopus.com/inward/record.url?scp=85046731142&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85046731142&partnerID=8YFLogxK
U2 - 10.1117/12.2290231
DO - 10.1117/12.2290231
M3 - Conference contribution
AN - SCOPUS:85046731142
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVI
A2 - Vo-Dinh, Tuan
A2 - Grundfest, Warren S.
A2 - Mahadevan-Jansen, Anita
PB - SPIE
T2 - Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVI 2018
Y2 - 28 January 2018 through 30 January 2018
ER -