Simultaneous, noninvasive, in vivo, continuous monitoring of hematocrit, vascular volume, hemoglobin oxygen saturation, pulse rate and breathing rate in humans and other animal models using a single light source

Paul Dent, Sai Han Tun, Seth Fillioe, Bin Deng, Josh Satalin, Gary Nieman, Kailyn Wilcox, Quinn Searles, Sri Narsipur, Charles M. Peterson, Jerry Goodisman, James Mostrom, Richard Steinmann, J. Chaiken

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

We previously reported a new algorithm "PV[O]H" for continuous, noninvasive, in vivo monitoring of hematocrit changes in blood and have since shown its utility for monitoring in humans during 1) hemodialysis, 2) orthostatic perturbations and 3) during blood loss and fluid replacement in a rat model. We now show that the algorithm is sensitive to changes in hemoglobin oxygen saturation. We document the phenomenology of the effect and explain the effect using new results obtained from humans and rat models. The oxygen sensitivity derives from the differential absorption of autofluorescence originating in the static tissues by oxy and deoxy hemoglobin. Using this approach we show how to perform simultaneous, noninvasive, in vivo, continuous monitoring of hematocrit, vascular volume, hemoglobin oxygen saturation, pulse rate and breathing rate in mammals using a single light source. We suspect that monitoring of changes in this suite of vital signs can be provided with improved time response, sensitivity and precision compared to existing methodologies. Initial results also offer a more detailed glimpse into the systemic oxygen transport in the circulatory system of humans.

Original languageEnglish (US)
Title of host publicationAdvanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVI
EditorsTuan Vo-Dinh, Warren S. Grundfest, Anita Mahadevan-Jansen
PublisherSPIE
ISBN (Electronic)9781510614536
DOIs
StatePublished - Jan 1 2018
EventAdvanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVI 2018 - San Francisco, United States
Duration: Jan 28 2018Jan 30 2018

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10484
ISSN (Print)1605-7422

Other

OtherAdvanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVI 2018
CountryUnited States
CitySan Francisco
Period1/28/181/30/18

Keywords

  • Hematocrit
  • SPO2
  • breathing rate
  • continuous
  • noninvasive
  • vascular volume
  • vital sign monitoring

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Dent, P., Tun, S. H., Fillioe, S., Deng, B., Satalin, J., Nieman, G., Wilcox, K., Searles, Q., Narsipur, S., Peterson, C. M., Goodisman, J., Mostrom, J., Steinmann, R., & Chaiken, J. (2018). Simultaneous, noninvasive, in vivo, continuous monitoring of hematocrit, vascular volume, hemoglobin oxygen saturation, pulse rate and breathing rate in humans and other animal models using a single light source. In T. Vo-Dinh, W. S. Grundfest, & A. Mahadevan-Jansen (Eds.), Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVI [1048410] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10484). SPIE. https://doi.org/10.1117/12.2290231