Ship Inhibitors and Uses Thereof

John D. Chisholm (Inventor), William G. Kerr (Inventor)

Research output: Patent

Abstract

The present invention relates to SHIP inhibitor compounds and methods for using these compounds. In particular, the present invention discloses the following methods: (i) a method of treating graft versus host disease in a subject; (ii) a method of inhibiting a SHIP1 protein in a cell; (iii) a method of selectively inhibiting a SHIP1 protein in a cell; (iv) a method for treating or preventing graft-versus-host disease (GVHD) in a recipient of an organ or tissue transplant; (v) a method of modulating SHIP activity in a cell expressing SHIP1 or SHIP2; (vi) a method of ex vivo or in vitro treatment of transplants; (vii) a method of inhibiting tumor growth and metastasis in a subject; (viii) a method of treating a hematologic malignancy in a subject; (ix) a method of inducing apoptosis of multiple myeloma cells; (x) a method of treating multiple myeloma in a subject; (xi) a method of inhibiting the proliferation of a human breast cancer cell; and (xii) a method of treating breast cancer in a subject.
Original languageEnglish (US)
Patent number9,447,139
StatePublished - Apr 25 2013

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Ships
Graft vs Host Disease
Multiple Myeloma
Transplants
Breast Neoplasms
Hematologic Neoplasms

Cite this

Chisholm, J. D., & Kerr, W. G. (2013). Ship Inhibitors and Uses Thereof. (Patent No. 9,447,139).

Ship Inhibitors and Uses Thereof. / Chisholm, John D. (Inventor); Kerr, William G. (Inventor).

Patent No.: 9,447,139.

Research output: Patent

Chisholm, JD & Kerr, WG 2013, Ship Inhibitors and Uses Thereof, Patent No. 9,447,139.
Chisholm JD, Kerr WG, inventors. Ship Inhibitors and Uses Thereof. 9,447,139. 2013 Apr 25.
Chisholm, John D. (Inventor) ; Kerr, William G. (Inventor). / Ship Inhibitors and Uses Thereof. Patent No.: 9,447,139.
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