Shape memory scaffold with a tunable recovery temperature for filling critical-size bone defects

R. M. Baker, J. H. Henderson, P. T. Mather

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Traditionally, critical-size defects have been treated using autologous bone grafts which, while being effective, have limitations that include donor site scarcity, additional pain, and donor site morbidity. Synthetic scaffolds show promise as alternate graft materials, but current scaffolds have limitations associated with filling and conforming to the defect site. In this study, we aimed to synthesize a cytocompatible scaffold with shape memory functionality that could address limitations associated with filling and conforming to the defect site. To achieve this goal we employed a porogen-leaching technique to fabricate a shape memory poly(epsilon- caprolactone) (PCL) foam capable of expanding to fill space under physiological temperatures. Tuning of the recovery temperature to a physiological temperature was achieved by copolymerizing with a second, hydrophilic polymer, as well as by varying the deformation temperature. The scaffold showed excellent shape fixing and shape recovery, and the transition temperature was tuned to a physiological range. Preliminary cell studies showed qualitatively that cells remain viable and proliferate on the scaffold.

Original languageEnglish (US)
Title of host publicationProceedings - 39th Annual Northeast Bioengineering Conference, NEBEC 2013
Pages55-56
Number of pages2
DOIs
StatePublished - Nov 8 2013
Event39th Annual Northeast Bioengineering Conference, NEBEC 2013 - Syracuse, NY, United States
Duration: Apr 5 2013Apr 7 2013

Publication series

NameProceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
ISSN (Print)1071-121X
ISSN (Electronic)2160-7001

Other

Other39th Annual Northeast Bioengineering Conference, NEBEC 2013
CountryUnited States
CitySyracuse, NY
Period4/5/134/7/13

Keywords

  • bone tissue engineering
  • scaffold
  • shape memory polymer

ASJC Scopus subject areas

  • Bioengineering

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  • Cite this

    Baker, R. M., Henderson, J. H., & Mather, P. T. (2013). Shape memory scaffold with a tunable recovery temperature for filling critical-size bone defects. In Proceedings - 39th Annual Northeast Bioengineering Conference, NEBEC 2013 (pp. 55-56). [6574354] (Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC). https://doi.org/10.1109/NEBEC.2013.159