A shape memory polymer hydrogel that is biodegradable, includes antimicrobial agents, and has a tunable drug delivery is used for wound healing internally and externally. The shape memory polymer is synthesized using a combination of hydrophilic precursors that are configured to have two to four functional end groups, with at least one component that has at least three functional groups. The synthesis route provides for a covalently crosslinked thermoset hydrogel. The chemistry can be tuned to provide desired transition temperatures for delivery (e.g. below 37° C.) and desired pore sizes for healing (e.g. 250-500 μm).
|Original language||English (US)|
|State||Published - Jul 7 2022|