Sex-differentiated associations among negative parenting, emotion-related brain function, and adolescent substance use and psychopathology symptoms

Tara M. Chaplin, Jennifer A. Poon, James C. Thompson, Amysue Hansen, Sarah L. Dziura, Caitlin C. Turpyn, Claire E. Niehaus, Rajita Sinha, Laurie Chassin, Emily Ansell

Research output: Contribution to journalArticle

Abstract

Parenting is a critical factor in adolescent social–emotional development, with maladaptive parenting leading to risk for the development of psychopathology. However, the emotion-related brain mechanisms underlying the influence of parenting on psychopathology symptoms are unknown. The present study utilized functional magnetic resonance imaging and laboratory measures to examine sex-differentiated associations among parenting, adolescent emotion-related brain function, and substance use and psychopathology symptoms in 66 12–14-year olds. Maternal parenting behaviors (warmth, negative parenting) were observed in a laboratory task. Adolescent brain responses to negative emotional stimuli were assessed in emotion processing regions of interest (left [L] and right [R] amygdala, anterior insula, and anterior cingulate cortex [ACC]). Adolescents reported on substance use and depressive, anxiety, and externalizing symptoms. Maternal negative parenting predicted adolescent brain activation differently by sex. For girls, negative parenting predicted heightened R ACC activation to negative emotional stimuli. For boys, negative parenting predicted blunted L and R anterior insula and L ACC activation. Furthermore, for girls, but not boys, heightened L anterior insula and heightened L and R ACC activation were associated with substance use and depressive symptoms, respectively. Findings suggest neural response to negative emotion as a possible sex-specific pathway from negative parenting to psychopathology.

Original languageEnglish (US)
JournalSocial Development
DOIs
StatePublished - Jan 1 2019

Fingerprint

Parenting
psychopathology
Psychopathology
brain
Emotions
emotion
activation
adolescent
Brain
Gyrus Cinguli
stimulus
anxiety
Adolescent Development
Maternal Behavior
Amygdala
Anxiety
Mothers
Magnetic Resonance Imaging
Depression

Keywords

  • adolescence
  • developmental psychopathology
  • fMRI
  • parenting; emotion

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Sociology and Political Science
  • Social Sciences (miscellaneous)

Cite this

Sex-differentiated associations among negative parenting, emotion-related brain function, and adolescent substance use and psychopathology symptoms. / Chaplin, Tara M.; Poon, Jennifer A.; Thompson, James C.; Hansen, Amysue; Dziura, Sarah L.; Turpyn, Caitlin C.; Niehaus, Claire E.; Sinha, Rajita; Chassin, Laurie; Ansell, Emily.

In: Social Development, 01.01.2019.

Research output: Contribution to journalArticle

Chaplin, Tara M. ; Poon, Jennifer A. ; Thompson, James C. ; Hansen, Amysue ; Dziura, Sarah L. ; Turpyn, Caitlin C. ; Niehaus, Claire E. ; Sinha, Rajita ; Chassin, Laurie ; Ansell, Emily. / Sex-differentiated associations among negative parenting, emotion-related brain function, and adolescent substance use and psychopathology symptoms. In: Social Development. 2019.
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