Severity of central sleep apnea does not affect sleeping oxygen saturation during ascent to high altitude

Jordan D. Bird, Anne Kalker, Alexander N. Rimke, Jason S. Chan, Garrick Chan, Gurkarn Saran, Nicholas G. Jendzjowsky, Richard J.A. Wilson, Thomas D. Brutsaert, Mingma T. Sherpa, Trevor A. Day

Research output: Contribution to journalArticlepeer-review

Abstract

Central sleep apnea (CSA) is characterized by periodic breathing (PB) during sleep, defined as intermittent periods of apnea/hypopnea and hyperventilation, with associated acute fluctuations in oxyhemoglobin saturation (SO2). CSA has an incidence of ∼50% in heart failure patients but is universal at high altitude (HA; _2,500 m), increasing in severity with further ascent and/or time at altitude. However, whether PB is adaptive, maladaptive, or neutral with respect to sleeping SO2 at altitude is unclear. We hypothesized that PB severity would improve mean sleeping SO2 during acclimatization to HA due to relative, intermittent hyperventilation subsequent to each apnea. We utilized portable sleep monitors to assess the incidence and severity of CSA via apnea-hypopnea index (AHI) and oxygen desaturation index (ODI), and peripheral oxygen saturation (SpO2 ) during sleep during two ascent profiles to HA in native lowlanders: 1) rapid ascent to and residence at 3,800 m for 9 days/nights (n = 21) and 2) incremental ascent to 5,160 m over 10 days/ nights (n = 21). In both ascent models, severity of AHI and ODI increased and mean sleeping SpO2 decreased, as expected. However, during sleep on the last night/highest altitude of both ascent profiles, neither AHI nor ODI were correlated with mean sleeping SpO2 . In addition, mean sleeping SpO2 was not significantly different between high and low CSA. These data suggest that CSA is neither adaptive nor maladaptive with regard to mean oxygen saturation during sleep, owing to the relative hyperventilation between apneas, likely correcting transient apnea-mediated oxygen desaturation and maintaining mean oxygenation.

Original languageEnglish (US)
Pages (from-to)1432-1443
Number of pages12
JournalJournal of Applied Physiology
Volume131
Issue number5
DOIs
StatePublished - Nov 2021

Keywords

  • Central sleep apnea
  • High-altitude ascent
  • Oxygen saturation
  • Periodic breathing
  • Respiratory chemoreflexes

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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