Seroprevalence of hepatitis E virus antibodies in adults and children from upstate New York: A cross-sectional study

Brittany L Kmush, Amelia M Lu, Taylor Spillane, Bryce Hruska, Brooks B Gump, Kestutis G Bendinskas

Research output: Contribution to journalArticlepeer-review

Abstract

Hepatitis E virus (HEV) is a major cause of viral hepatitis around the world, especially in developing countries. Recently, HEV has also been recognized as important cause of hepatitis in Europe and Japan, however, there is a paucity of clinical data from the United States. The overall seroprevalence of HEV antibodies is around 10% in the United States, but considerable variation is seen based on geographic location, year, and assay used. In this study, 63 adults and 417 children from New York State were tested for anti-HEV IgG antibodies using the commercially available Wantai IgG assay. The overall seroprevalence of HEV antibodies among adult participants was 9.52% (95% CI: 3.58-19.59%). Positive adults tended to be older than HEV negative adults, all positive adults were female. Only 3 (0.7%, 95% CI:: 0.15-2.09%) of the children were positive, all positive children were male. These results are consistent with global and United States trends in HEV seroprevalence.

Original languageEnglish (US)
Pages (from-to)e0245850
JournalPloS one
Volume16
Issue number1
DOIs
StatePublished - 2021

Fingerprint Dive into the research topics of 'Seroprevalence of hepatitis E virus antibodies in adults and children from upstate New York: A cross-sectional study'. Together they form a unique fingerprint.

Cite this