The sequential insertion of carbon monoxide and imines has been achieved at ambient temperatures with cationic nickel complexes, yielding the nickel-chelated amides (bipy)Ni[η2-C(H)TolN(R)COCH3]+X-(bipy = 2,2′-bipyridyl; Tol = p-tolyl; R = alkyl, aryl; X = OTf, PF6, SbF6, B(3,5-C6H3(CF3)2)4). The addition of KCN/methanol to these products of CO/imine insertion leads to cleavage of the amide ligand, providing a facile method to achieve the overall hydroacylation of imines under mild conditions.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry