Sequence specificity of drug-DNA interactions

James C. Dabrowiak

doi:10.1016/0024-3205(83)90642-2

Sequence specificity of drug-DNA interactions

James C. Dabrowiak

Department of Chemistry

Research output: Contribution to journal › Short Survey Article › peer-review

37 Scopus citations

Abstract

Methods for determining sequence specificities of anticancer drugs, carcinogens, and mutagens which interact with natural DNS's are presented. For drugs which nick or covalently bind to DNA and thus leave a permanent record of their residence position on the helix, the sequences important in drug action can be readily determined. For agents which interact with DNA in an equilibrium fashion, "footprinting" analysis, a technique used to investigate protein-DNA binding, has proved to be useful in stydying drug-DNA interactions. The sequence specificities of a number of small ligands which interact with natural DNA's are also presented.

Original language	English (US)
Pages (from-to)	2915-2931
Number of pages	17
Journal	Life Sciences
Volume	32
Issue number	26
DOIs	https://doi.org/10.1016/0024-3205(83)90642-2
State	Published - Jun 27 1983

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(83)90642-2

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N2 - Methods for determining sequence specificities of anticancer drugs, carcinogens, and mutagens which interact with natural DNS's are presented. For drugs which nick or covalently bind to DNA and thus leave a permanent record of their residence position on the helix, the sequences important in drug action can be readily determined. For agents which interact with DNA in an equilibrium fashion, "footprinting" analysis, a technique used to investigate protein-DNA binding, has proved to be useful in stydying drug-DNA interactions. The sequence specificities of a number of small ligands which interact with natural DNA's are also presented.

AB - Methods for determining sequence specificities of anticancer drugs, carcinogens, and mutagens which interact with natural DNS's are presented. For drugs which nick or covalently bind to DNA and thus leave a permanent record of their residence position on the helix, the sequences important in drug action can be readily determined. For agents which interact with DNA in an equilibrium fashion, "footprinting" analysis, a technique used to investigate protein-DNA binding, has proved to be useful in stydying drug-DNA interactions. The sequence specificities of a number of small ligands which interact with natural DNA's are also presented.

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U2 - 10.1016/0024-3205(83)90642-2

DO - 10.1016/0024-3205(83)90642-2

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JO - Life Sciences

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ER -

Sequence specificity of drug-DNA interactions

Abstract

ASJC Scopus subject areas

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