Sequence specificity of drug-DNA interactions

James C. Dabrowiak

Research output: Contribution to journalShort survey

35 Scopus citations

Abstract

Methods for determining sequence specificities of anticancer drugs, carcinogens, and mutagens which interact with natural DNS's are presented. For drugs which nick or covalently bind to DNA and thus leave a permanent record of their residence position on the helix, the sequences important in drug action can be readily determined. For agents which interact with DNA in an equilibrium fashion, "footprinting" analysis, a technique used to investigate protein-DNA binding, has proved to be useful in stydying drug-DNA interactions. The sequence specificities of a number of small ligands which interact with natural DNA's are also presented.

Original languageEnglish (US)
Pages (from-to)2915-2931
Number of pages17
JournalLife Sciences
Volume32
Issue number26
DOIs
StatePublished - Jun 27 1983

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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