TY - JOUR
T1 - Sensing the unreachable
T2 - challenges and opportunities in biofilm detection
AU - Xu, Yikang
AU - Dhaouadi, Yousr
AU - Stoodley, Paul
AU - Ren, Dacheng
N1 - Funding Information:
The authors thank the U.S. National Science Foundation for an ERC planning grant (1936926), which facilitates discussions of future research on microbial control and partially led to this review article. PS is funded by the NIH R01GM124436. DR's current research on catheters is supported by NIH 1R21AI142424-01.
Funding Information:
The authors thank the U.S. National Science Foundation for an ERC planning grant ( 1936926 ), which facilitates discussions of future research on microbial control and partially led to this review article. PS is funded by the NIH R01GM124436. DR's current research on catheters is supported by NIH 1R21AI142424-01.
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2020/8
Y1 - 2020/8
N2 - Bacteria can attach to essentially all materials and form multicellular biofilms with high-level tolerance to antimicrobials. Detrimental biofilms are responsible for a variety of problems ranging from food and water contamination, bio-corrosion, to drug resistant infections. Besides the challenges in control, biofilms are also difficult to detect due to the lack of biofilm-specific biomarkers and methods for non-destructive imaging. In this article, we present a concise review of recent advancements in this field, with a focus on medical device-associated infections. We also discuss the technologies that have potential for non-destructive detection of bacterial biofilms.
AB - Bacteria can attach to essentially all materials and form multicellular biofilms with high-level tolerance to antimicrobials. Detrimental biofilms are responsible for a variety of problems ranging from food and water contamination, bio-corrosion, to drug resistant infections. Besides the challenges in control, biofilms are also difficult to detect due to the lack of biofilm-specific biomarkers and methods for non-destructive imaging. In this article, we present a concise review of recent advancements in this field, with a focus on medical device-associated infections. We also discuss the technologies that have potential for non-destructive detection of bacterial biofilms.
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U2 - 10.1016/j.copbio.2019.10.009
DO - 10.1016/j.copbio.2019.10.009
M3 - Review article
C2 - 31766008
AN - SCOPUS:85075264232
SN - 0958-1669
VL - 64
SP - 79
EP - 84
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
ER -