Sensing nucleic acids with dimer nanoclusters

Cheng Chi, Mathew M. Maye, Andrea L. Stadler, Daniel Van Der Lelie, Oleg Gang

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


DNA linked nanoparticles are applied as a sensor for single-stranded DNA detection. The detection is based on nanocluster dimer disassembly triggered by the binding of target nucleic acid strands. Target detection and disassembly kinetics are followed in real-time using dynamic light scattering. The observed disassembly process is in agreement with a two-step kinetic model. The DNA sensing is found to be selective down to the level of a single base mismatch, even in the presence of a high concentration of interference DNA. The method further provides label-free detection of DNA in minutes and demonstrates the use of this new class of nanoclusters as a powerful platform for nucleic acid detection.

Original languageEnglish (US)
Pages (from-to)1051-1057
Number of pages7
JournalAdvanced Functional Materials
Issue number6
StatePublished - Mar 22 2011


  • DNA
  • detection
  • nanoclusters
  • nanoparticles

ASJC Scopus subject areas

  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics


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