Self-Assembling Catalytic Peptide Nanomaterials Capable of Highly Efficient Peroxidase Activity

Oleksii Zozulia, Liam R. Marshall, Inhye Kim, Eric M. Kohn, Ivan V. Korendovych

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


The self-assembly of short peptides gives rise to versatile nanomaterials capable of promoting efficient catalysis. We have shown that short, seven-residue peptides bind hemin to produce functional catalytic materials which display highly efficient peroxidation activity, reaching a catalytic efficiency of 3×105 m−1 s−1. Self-assembly is essential for catalysis as non-assembling controls show no activity. We have also observed peroxidase activity even in the absence of hemin, suggesting the potential to alter redox properties of substrates upon association with the assemblies. These results demonstrate the practical utility of self-assembled peptides in various catalytic applications and further support the evolutionary link between amyloids and modern-day enzymes.

Original languageEnglish (US)
Pages (from-to)5388-5392
Number of pages5
JournalChemistry - A European Journal
Issue number17
StatePublished - Mar 22 2021


  • amyloids
  • enzyme catalysis
  • peptides
  • peroxidases
  • self-assembly

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry


Dive into the research topics of 'Self-Assembling Catalytic Peptide Nanomaterials Capable of Highly Efficient Peroxidase Activity'. Together they form a unique fingerprint.

Cite this