Selective sparing of brain tissue in postmenopausal women receiving hormone replacement therapy

Kirk I. Erickson; Stanley J. Colcombe; Naftali Raz; Donna L. Korol; Paige Scalf; Andrew Webb; Neal J. Cohen; Edward McAuley; Arthur F. Kramer

doi:10.1016/j.neurobiolaging.2004.11.009

Selective sparing of brain tissue in postmenopausal women receiving hormone replacement therapy

Kirk I. Erickson, Stanley J. Colcombe, Naftali Raz, Donna L. Korol, Paige Scalf, Andrew Webb, Neal J. Cohen, Edward McAuley, Arthur F. Kramer

Research output: Contribution to journal › Article › peer-review

96 Scopus citations

Abstract

Determining the benefits and/or drawbacks of hormone replacement therapy (HRT) on women's health is an imperative public health goal. Research in rodents suggests benefits of estrogen on neuronal growth and function. However, little research has investigated the effects of HRT on brain tissue in humans. We used high-resolution magnetic resonance imaging and an optimized voxel-based morphometric technique to examine the effects of HRT on brain volume in postmenopausal women. We report two main results: (a) HRT is associated with the sparing of grey matter in prefrontal, parietal, and temporal brain regions and white matter in medial temporal lobe regions, and (b) longer durations of therapy are associated with greater sparing of grey matter tissue. HRT should be considered a possible mediator of age-related neural decline in both grey and white matter tissues.

Original language	English (US)
Pages (from-to)	1205-1213
Number of pages	9
Journal	Neurobiology of Aging
Volume	26
Issue number	8
DOIs	https://doi.org/10.1016/j.neurobiolaging.2004.11.009
State	Published - Aug 2005
Externally published	Yes

Keywords

Aging
Estrogen
Hippocampus
Hormone replacement therapy
MRI
Parietal cortex
Prefrontal cortex
Temporal cortex
Voxel-based morphometry

ASJC Scopus subject areas

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/j.neurobiolaging.2004.11.009

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title = "Selective sparing of brain tissue in postmenopausal women receiving hormone replacement therapy",

abstract = "Determining the benefits and/or drawbacks of hormone replacement therapy (HRT) on women's health is an imperative public health goal. Research in rodents suggests benefits of estrogen on neuronal growth and function. However, little research has investigated the effects of HRT on brain tissue in humans. We used high-resolution magnetic resonance imaging and an optimized voxel-based morphometric technique to examine the effects of HRT on brain volume in postmenopausal women. We report two main results: (a) HRT is associated with the sparing of grey matter in prefrontal, parietal, and temporal brain regions and white matter in medial temporal lobe regions, and (b) longer durations of therapy are associated with greater sparing of grey matter tissue. HRT should be considered a possible mediator of age-related neural decline in both grey and white matter tissues.",

keywords = "Aging, Estrogen, Hippocampus, Hormone replacement therapy, MRI, Parietal cortex, Prefrontal cortex, Temporal cortex, Voxel-based morphometry",

author = "Erickson, {Kirk I.} and Colcombe, {Stanley J.} and Naftali Raz and Korol, {Donna L.} and Paige Scalf and Andrew Webb and Cohen, {Neal J.} and Edward McAuley and Kramer, {Arthur F.}",

note = "Funding Information: We would like to thank the following people for their assistance in collection of the data: Barbara Suever, Ensar Becic, Holly Tracy, Nancy Dodge, Tracey Wszalek, Luis Mejia, Jadwiga Plachy, Sara Hartwick, Stephanie Badalementi, Nafisa Mandani, and Ritu Mehta. This research was supported by grants from the National Institutes on Aging (RO1 AG21887) and the Institute for the Study of Aging.",

year = "2005",

month = aug,

doi = "10.1016/j.neurobiolaging.2004.11.009",

language = "English (US)",

volume = "26",

pages = "1205--1213",

journal = "Neurobiology of Aging",

issn = "0197-4580",

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TY - JOUR

T1 - Selective sparing of brain tissue in postmenopausal women receiving hormone replacement therapy

AU - Erickson, Kirk I.

AU - Colcombe, Stanley J.

AU - Raz, Naftali

AU - Korol, Donna L.

AU - Scalf, Paige

AU - Webb, Andrew

AU - Cohen, Neal J.

AU - McAuley, Edward

AU - Kramer, Arthur F.

N1 - Funding Information: We would like to thank the following people for their assistance in collection of the data: Barbara Suever, Ensar Becic, Holly Tracy, Nancy Dodge, Tracey Wszalek, Luis Mejia, Jadwiga Plachy, Sara Hartwick, Stephanie Badalementi, Nafisa Mandani, and Ritu Mehta. This research was supported by grants from the National Institutes on Aging (RO1 AG21887) and the Institute for the Study of Aging.

PY - 2005/8

Y1 - 2005/8

N2 - Determining the benefits and/or drawbacks of hormone replacement therapy (HRT) on women's health is an imperative public health goal. Research in rodents suggests benefits of estrogen on neuronal growth and function. However, little research has investigated the effects of HRT on brain tissue in humans. We used high-resolution magnetic resonance imaging and an optimized voxel-based morphometric technique to examine the effects of HRT on brain volume in postmenopausal women. We report two main results: (a) HRT is associated with the sparing of grey matter in prefrontal, parietal, and temporal brain regions and white matter in medial temporal lobe regions, and (b) longer durations of therapy are associated with greater sparing of grey matter tissue. HRT should be considered a possible mediator of age-related neural decline in both grey and white matter tissues.

AB - Determining the benefits and/or drawbacks of hormone replacement therapy (HRT) on women's health is an imperative public health goal. Research in rodents suggests benefits of estrogen on neuronal growth and function. However, little research has investigated the effects of HRT on brain tissue in humans. We used high-resolution magnetic resonance imaging and an optimized voxel-based morphometric technique to examine the effects of HRT on brain volume in postmenopausal women. We report two main results: (a) HRT is associated with the sparing of grey matter in prefrontal, parietal, and temporal brain regions and white matter in medial temporal lobe regions, and (b) longer durations of therapy are associated with greater sparing of grey matter tissue. HRT should be considered a possible mediator of age-related neural decline in both grey and white matter tissues.

KW - Aging

KW - Estrogen

KW - Hippocampus

KW - Hormone replacement therapy

KW - MRI

KW - Parietal cortex

KW - Prefrontal cortex

KW - Temporal cortex

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Selective sparing of brain tissue in postmenopausal women receiving hormone replacement therapy

Abstract

Keywords

ASJC Scopus subject areas

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