Thanks to recent machine learning model innovation and computing hardware advancement, the state-of-the-art of Deep Neural Network (DNN) is presenting human-level performance for many complex intelligent tasks in real-world applications. However, it also introduces ever-increasing security concerns for those intelligent systems. For example, the emerging adversarial attacks indicate that even very small and often imperceptible adversarial input perturbations can easily mislead the cognitive function of deep learning systems (DLS). Existing DNN adversarial studies are narrowly performed on the ideal software-level DNN models with a focus on single uncertainty factor, i.e. input perturbations, however, the impact of DNN model reshaping on adversarial attacks, which is introduced by various hardware-favorable techniques such as hash-based weight compression during modern DNN hardware implementation, has never been discussed. In this work, we for the first time investigate the multi-factor adversarial attack problem in practical model optimized deep learning systems by jointly considering the DNN model-reshaping (e.g. HashNet based deep compression) and the input perturbations. We first augment adversarial example generating method dedicated to the compressed DNN models by incorporating the software-based approaches and mathematical modeled DNN reshaping. We then conduct a comprehensive robustness and vulnerability analysis of deep compressed DNN models under derived adversarial attacks. A defense technique named 'gradient inhibition' is further developed to ease the generating of adversarial examples thus to effectively mitigate adversarial attacks towards both software and hardware-oriented DNNs. Simulation results show that 'gradient inhibition' can decrease the average success rate of adversarial attacks from 87.99% to 4.77% (from 86.74% to 4.64%) on MNIST (CIFAR-10) benchmark with marginal accuracy degradation across various DNNs.