TY - JOUR
T1 - Scopolamine-induced deficits in spontaneous alternation performance
T2 - Attenuation with lateral ventricle injections of glucose
AU - Parsons, Michael W.
AU - Gold, Paul E.
N1 - Funding Information:
When injected systemically or released into the circulation from the adrenal medulla, epinephrine regulates memory storage processing (cf. McGaugh, 1989). The evidence includes demonstrations that post-training administration of epinephrine enhances memory for a wide range of learned responses, including performance tested in avoidance and appetitive tasks. Furthermore, post-training plasma-epinephrine levels predict later retention performance in rats under several conditions. Because circulating epinephrine is largely excluded from the central nervous system, it is likely that peripheral actions mediate the effects of the Present address: The Department of Psychology,U niversity of Texas, Austin, TX 78712. 2 This work was supported by research grants from ONR (N0001489-J-1216), NIA (AG 07648), and NSF (BNS-9012239). Address reprint requests to Dr. Paul E. Gold.
PY - 1992/1
Y1 - 1992/1
N2 - This experiment determined whether centrally administered glucose can attenuate scopolamine-induced deficits in spontaneous alternation performance. All rats were surgically prepared with indwelling cannulae directed at the lateral ventricle. Thirty min prior to alternation tests, rats received systemic (ip) injections of saline or scopolamine (3 mg/kg). Ten or thirty min prior to training, the rats also received a direct injection into the lateral ventricle of either artificial cerebrospinal fluid (CSF) or glucose (3 μg in 1 μl). Scopolamine significantly impaired spontaneous alternation performance relative to controls. Additional treatment with ICV glucose 30 min, but not 10 min prior to testing, significantly attenuated the scopolamine-induced deficit. These results add support to the view that glucose acts directly on brain systems to attenuate behavioral effects of cholinergic antagonists.
AB - This experiment determined whether centrally administered glucose can attenuate scopolamine-induced deficits in spontaneous alternation performance. All rats were surgically prepared with indwelling cannulae directed at the lateral ventricle. Thirty min prior to alternation tests, rats received systemic (ip) injections of saline or scopolamine (3 mg/kg). Ten or thirty min prior to training, the rats also received a direct injection into the lateral ventricle of either artificial cerebrospinal fluid (CSF) or glucose (3 μg in 1 μl). Scopolamine significantly impaired spontaneous alternation performance relative to controls. Additional treatment with ICV glucose 30 min, but not 10 min prior to testing, significantly attenuated the scopolamine-induced deficit. These results add support to the view that glucose acts directly on brain systems to attenuate behavioral effects of cholinergic antagonists.
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U2 - 10.1016/0163-1047(92)90801-A
DO - 10.1016/0163-1047(92)90801-A
M3 - Article
C2 - 1567337
AN - SCOPUS:0026583719
SN - 0163-1047
VL - 57
SP - 90
EP - 92
JO - Behavioral and Neural Biology
JF - Behavioral and Neural Biology
IS - 1
ER -