Ruthenium dihydride complexes as enyne metathesis catalysts

Martin A. Dolan, Alexandre D.C. Dixon, John D. Chisholm, Daniel A Clark

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Ruthenium–catalyzed enyne metathesis is a reliable and efficient method for the formation of 1,3-dienes, a common structural motif in synthetic organic chemistry. The development of new transition-metal complexes competent to catalyze enyne metathesis reactions remains an important research area. This report describes the use of ruthenium (IV) dihydride complexes with the general structure RuH2Cl2(PR3)2 as new catalysts for enyne metathesis. These ruthenium (IV) dihydrides have been largely unexplored as catalysts in metathesis-based transformations. The reactivity of these complexes with 1,6 and 1,7-enynes was investigated. The observed reaction products are consistent with the metathesis activity occurring through a ruthenium vinylidene intermediate.

Original languageEnglish (US)
Pages (from-to)4471-4474
Number of pages4
JournalTetrahedron Letters
Volume59
Issue number51
DOIs
StatePublished - Dec 19 2018

Keywords

  • 1,3-Diene
  • Alkyne
  • Dihydride
  • Enyne
  • Metathesis
  • Ruthenium

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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