Ruthenium catalyzed cycloisomerization of silicon-tethered 1,7-enynes to give exocyclic 1,3-dienes

Lauren Kaminsky, Daniel A. Clark

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The cycloisomerization of vinyl silicon-tethered 1,7-enynes has been accomplished using catalytic Cp∗Ru(COD)Cl. The products possess a new silane moiety and trisubstituted alkenes as part of the diene system. The reaction scope includes aryl, alkyl, vinyl, and cyclopropyl alkyne functionalities. Silicon was found not to be a mandatory component of the tether. The utility of the products was demonstrated through manipulation of the vinyl silane and Diels-Alder chemistry. (Chemical Equation Presented).

Original languageEnglish (US)
Pages (from-to)5450-5453
Number of pages4
JournalOrganic Letters
Volume16
Issue number20
DOIs
StatePublished - Oct 17 2014

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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