Risk factors for hepatitis E virus infection and disease

Brittany L. Kmush, Kenrad E. Nelson, Alain B. Labrique

Research output: Contribution to journalReview article

21 Scopus citations


Hepatitis E, caused by hepatitis E virus, is a disease of global significance, causing 20 million infections each year. Genotypes 1 and 2 have vastly different epidemiological patterns from genotypes 3 and 4. In genotype 1 and 2 endemic areas, most infections and illness occur in persons 15-30 years of age, with pregnant women being the most likely to experience severe disease. In genotype 3 and 4 endemic areas, most infections and illness occur in those of age 40-60 years, with males representing a large portion of those with severe disease. However, the lack of an easily accessible serologic assay in many countries continues to be a barrier to the diagnosis and recognition of hepatitis E virus.

Original languageEnglish (US)
Pages (from-to)41-53
Number of pages13
JournalExpert Review of Anti-Infective Therapy
Issue number1
StatePublished - Jan 1 2015



  • asymptomatic infection
  • epidemiology
  • hepatitis E
  • hepatitis E virus
  • risk factors
  • severe disease

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology
  • Virology
  • Medicine(all)

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