Rhodium-catalyzed addition of aryl boronic acids to 1,2-diketones and 1,2-ketoesters

Gregory R. Ganci, John D. Chisholm

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

The metal complex Rh(acac)(CO)2 in the presence of dicyclohexylphenylphosphine provides a useful catalyst system for the addition of boronic acids to 1,2-diketones and 1,2-ketoesters. The best yields were obtained when the transformation was performed in DME/H2O at 80 °C with 4 equiv of the boronic acid. The results discussed herein extend the scope of the addition of arylboronic acids to highly activated diketones and ketoesters. The products of the reaction are useful in the synthesis of natural products containing oxygenation next to esters or ketones.

Original languageEnglish (US)
Pages (from-to)8266-8269
Number of pages4
JournalTetrahedron Letters
Volume48
Issue number47
DOIs
StatePublished - Nov 19 2007

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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