Reversal of guanethidine- and diethyldithiocarbamate-induced amnesia by peripherally-administered catecholamines

Thomas J. Walsh, Tibor Palfai

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The effect of peripherally-administered catecholamines on guanethidine- and diethyldithiocarbamate-induced amnesia of a PA training in mice was investigated. The amnesic effect of guanethidine could be blocked with 50 mg/kg DA, or 0.75 mg/kg NE when given either before, immediately, or 10 min after but not 90 min following PA. Epinephrine or a lower dose of DA could not attenuate the guanethidine-induced amnesia. The amnesic effect of diethyldithiocarbamate could be blocked with 50 mg/kg DA, 0.75 mg/kg NE or 0.5 mg/kg E when given either before, immediately or 10 min after but not 90 min following PA. The amnesic effects of these compounds were interpreted in terms of their peripheral antiadrenergic actions.

Original languageEnglish (US)
Pages (from-to)713-718
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume14
Issue number5
DOIs
StatePublished - May 1981

Keywords

  • Amnesia
  • Antiadrenergic drugs
  • Biogenic amines
  • Memory

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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