Retrograde amnesia produced by several treatments: Evidence for a common neurobiological mechanism

Paul E. Gold, Debra B. Sternberg

Research output: Contribution to journalArticle

90 Scopus citations

Abstract

This experiment examined the effects on memory of various amnestic treatments in animals earlier treated with the α-adrenergic antagonist phenoxybenzamine (PBZ). Thirty minutes before being trained in a one-trial inhibitory (passive) avoidance task, animals received an injection of PBZ or saline. Immediately after training, each animal received one of the following amnestic treatments: stimulation of the frontal cortex or amygdala, pentylenetetrazol, diethyldithiocarbamate, or cycloheximide. In control animals, each treatment produced retrograde amnesia. However, PBZ-treated animals did not develop amnesia. These findings suggest that there may be a common neurobiological mechanism underlying the amnesias produced by many treatments.

Original languageEnglish (US)
Pages (from-to)367-369
Number of pages3
JournalScience
Volume201
Issue number4353
DOIs
StatePublished - Jan 1 1978
Externally publishedYes

ASJC Scopus subject areas

  • General

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