Abstract
Subseizure electrical stimulation of the amygdala produced retrograde amnesia for a visual discrimination shock-motivated task. Animals pretreated with the α-adrenergic antagonist phenoxybenzamine, or the β-adrenergic antagonist propranolol, did not develop amnesia. The findings indicate that adrenergic antagonists attenuate amnesia produced by amygdala stimulation for visual discrimination training. These results are consistent with previous evidence indicating that adrenergic antagonists attenuate the amnesias produced by a variety of agents, and thus, suggest that adrenergic mechanisms may be involved in the production of retrograde amnesia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 59-65 |
| Number of pages | 7 |
| Journal | Brain Research |
| Volume | 211 |
| Issue number | 1 |
| DOIs | |
| State | Published - Apr 27 1981 |
| Externally published | Yes |
Keywords
- adrenergic antagonists
- amygdala
- avoidance training
- catecholamines
- memory
- memory storage
- retrograde amnesia
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology