Retrograde amnesia gradients: Effects of direct cortical stimulation

Paul E. Gold, John Macri, James L. Mcgaugh

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Electrical stimulation was delivered bilaterally to either the anterior or posterior cortex in rats from 0.1 second to 4 hours after a single training trial on an inhibitory avoidance task. As indicated by a retention test given 24 hours later, the length of the retrograde amnesia gradients ranged from 5 seconds to 240 minutes, depending on the brain region stimulated and the intensity of the stimulating current. The stimulation intensity that was threshold for amnesia varied directly with the length of the interval between training and treatment.

Original languageEnglish (US)
Pages (from-to)1343-1345
Number of pages3
JournalScience
Volume179
Issue number4080
DOIs
StatePublished - Jan 1 1973
Externally publishedYes

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Retrograde amnesia gradients: Effects of direct cortical stimulation'. Together they form a unique fingerprint.

  • Cite this