Retrograde amnesia gradients: Effects of direct cortical stimulation

Paul Ernest Gold, John Macri, James L. Mcgaugh

Research output: Contribution to journalArticle

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Abstract

Electrical stimulation was delivered bilaterally to either the anterior or posterior cortex in rats from 0.1 second to 4 hours after a single training trial on an inhibitory avoidance task. As indicated by a retention test given 24 hours later, the length of the retrograde amnesia gradients ranged from 5 seconds to 240 minutes, depending on the brain region stimulated and the intensity of the stimulating current. The stimulation intensity that was threshold for amnesia varied directly with the length of the interval between training and treatment.

Original languageEnglish (US)
Pages (from-to)1343-1345
Number of pages3
JournalScience
Volume179
Issue number4080
StatePublished - 1973
Externally publishedYes

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Cite this

Gold, P. E., Macri, J., & Mcgaugh, J. L. (1973). Retrograde amnesia gradients: Effects of direct cortical stimulation. Science, 179(4080), 1343-1345.