Retrograde amnesia after localized brain shock in passive-avoidance learning

Paul E. Gold; William Farrell; Richard A. King

doi:10.1016/0031-9384(71)90136-3

Retrograde amnesia after localized brain shock in passive-avoidance learning

Paul E. Gold, William Farrell, Richard A. King

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Rats were trained on a one-trial passive-avoidance task. Post-trial brain shock was administered through skull screws. This stimulation was given through either anterior or posterior skull placements at several current intensities. At two intensities anterior stimulation was found to produce significantly more retrograde amnesia than the corresponding posterior stimulation. The results are discussed in terms of (a) possible lower generalized brain seizure thresholds for anterior shocks, and (b) possible post-trial disruption of activity in the specific anterior brain structures importantly involved in memory for passive-avoidance learning.

Original language	English (US)
Pages (from-to)	709-712
Number of pages	4
Journal	Physiology and Behavior
Volume	7
Issue number	5
DOIs	https://doi.org/10.1016/0031-9384(71)90136-3
State	Published - Nov 1971
Externally published	Yes

Keywords

ECS
Electroconvulsive shock
Localization of ECS effects
Memory
Passive-avoidance learning
Retrograde amnesia

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Behavioral Neuroscience

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10.1016/0031-9384(71)90136-3

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title = "Retrograde amnesia after localized brain shock in passive-avoidance learning",

abstract = "Rats were trained on a one-trial passive-avoidance task. Post-trial brain shock was administered through skull screws. This stimulation was given through either anterior or posterior skull placements at several current intensities. At two intensities anterior stimulation was found to produce significantly more retrograde amnesia than the corresponding posterior stimulation. The results are discussed in terms of (a) possible lower generalized brain seizure thresholds for anterior shocks, and (b) possible post-trial disruption of activity in the specific anterior brain structures importantly involved in memory for passive-avoidance learning.",

keywords = "ECS, Electroconvulsive shock, Localization of ECS effects, Memory, Passive-avoidance learning, Retrograde amnesia",

author = "Gold, {Paul E.} and William Farrell and King, {Richard A.}",

note = "Funding Information: Procedure. Three to seven days after surgery the rats were trained in the apparatus. The animal was placed on the safe side facing the door and was allowed to turn around until xStudy supported by PHS Training Grant ITO1-MH 11107. 2Now at the University of California, Irvine, Department of Psychobiology. 3Now at Stanford University, Department of Psychology. 4Reprints available from: Richard King, Psychology Department, University of North Carolina, Chapel Hill, North Carolina 27514, U.S.A.",

year = "1971",

month = nov,

doi = "10.1016/0031-9384(71)90136-3",

language = "English (US)",

volume = "7",

pages = "709--712",

journal = "Physiology and Behavior",

issn = "0031-9384",

publisher = "Elsevier",

number = "5",

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TY - JOUR

T1 - Retrograde amnesia after localized brain shock in passive-avoidance learning

AU - Gold, Paul E.

AU - Farrell, William

AU - King, Richard A.

N1 - Funding Information: Procedure. Three to seven days after surgery the rats were trained in the apparatus. The animal was placed on the safe side facing the door and was allowed to turn around until xStudy supported by PHS Training Grant ITO1-MH 11107. 2Now at the University of California, Irvine, Department of Psychobiology. 3Now at Stanford University, Department of Psychology. 4Reprints available from: Richard King, Psychology Department, University of North Carolina, Chapel Hill, North Carolina 27514, U.S.A.

PY - 1971/11

Y1 - 1971/11

N2 - Rats were trained on a one-trial passive-avoidance task. Post-trial brain shock was administered through skull screws. This stimulation was given through either anterior or posterior skull placements at several current intensities. At two intensities anterior stimulation was found to produce significantly more retrograde amnesia than the corresponding posterior stimulation. The results are discussed in terms of (a) possible lower generalized brain seizure thresholds for anterior shocks, and (b) possible post-trial disruption of activity in the specific anterior brain structures importantly involved in memory for passive-avoidance learning.

AB - Rats were trained on a one-trial passive-avoidance task. Post-trial brain shock was administered through skull screws. This stimulation was given through either anterior or posterior skull placements at several current intensities. At two intensities anterior stimulation was found to produce significantly more retrograde amnesia than the corresponding posterior stimulation. The results are discussed in terms of (a) possible lower generalized brain seizure thresholds for anterior shocks, and (b) possible post-trial disruption of activity in the specific anterior brain structures importantly involved in memory for passive-avoidance learning.

KW - ECS

KW - Electroconvulsive shock

KW - Localization of ECS effects

KW - Memory

KW - Passive-avoidance learning

KW - Retrograde amnesia

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VL - 7

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JO - Physiology and Behavior

JF - Physiology and Behavior

IS - 5

ER -

Retrograde amnesia after localized brain shock in passive-avoidance learning

Abstract

Keywords

ASJC Scopus subject areas

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