Abstract
We previously reported a relationship between prenatal PCB exposure and impulsive (excessive) responding on a continuous performance task in children at 4 1/2 years of age [P.W. Stewart, S. Fitzgerald, J. Reihman, B. Gump, E. Lonky, T. Darvill, J. Pagano, P. Hauser, Prenatal PCB exposure, the corpus callosum, and response inhibition, Environmental Health Perspectives 111 (13) (2003b) 1670-1677.]. The current study investigated the stability of this effect at 8 and 9 1/2 years of age. We tested the hypothesis that PCB-related impulsive responding might be a function of impaired response inhibition. Children (n = 202) enrolled in the Oswego Children's Study were tested at 8 years of age using the NES2 Continuous Performance Test (CPT). This was followed by a series of Extended Continuous Performance Tests (E-CPT) at 9 1/2 years of age, designed to dissociate response inhibition from sustained attention. After taking into account more than 50 measured covariables, including maternal IQ, maternal sustained attention and maternal response inhibition, results revealed PCB-related associations with impulsive responding at both testing ages. At 8 years of age, prenatal PCB exposure was associated with increased impulsive responding on the CPT. At 9 1/2 years of age, E-CPT testing clearly indicated that the PCB-related impulsive responding was due to impaired response inhibition and not impaired sustained attention. These results were significant after extensive and rigorous control for multiple potential confounders, including several non-PCB contaminants (prenatal MeHg, DDE, HCB, and pre- and postnatal Pb). These data are consistent with, and in fact predicted by, several studies in PCB-exposed animals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 771-780 |
| Number of pages | 10 |
| Journal | Neurotoxicology and Teratology |
| Volume | 27 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 2005 |
| Externally published | Yes |
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Keywords
- Continuous Performance Tests
- Impulsive responding
- Prenatal PCB exposure
- Response inhibition
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Neuroscience(all)
- Toxicology
Cite this
Response inhibition at 8 and 9 1/2 years of age in children prenatally exposed to PCBs. / Stewart, Paul; Reihman, Jacqueline; Gump, Brooks B; Lonky, Edward; Darvill, Thomas; Pagano, James.
In: Neurotoxicology and Teratology, Vol. 27, No. 6, 11.2005, p. 771-780.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Response inhibition at 8 and 9 1/2 years of age in children prenatally exposed to PCBs
AU - Stewart, Paul
AU - Reihman, Jacqueline
AU - Gump, Brooks B
AU - Lonky, Edward
AU - Darvill, Thomas
AU - Pagano, James
PY - 2005/11
Y1 - 2005/11
N2 - We previously reported a relationship between prenatal PCB exposure and impulsive (excessive) responding on a continuous performance task in children at 4 1/2 years of age [P.W. Stewart, S. Fitzgerald, J. Reihman, B. Gump, E. Lonky, T. Darvill, J. Pagano, P. Hauser, Prenatal PCB exposure, the corpus callosum, and response inhibition, Environmental Health Perspectives 111 (13) (2003b) 1670-1677.]. The current study investigated the stability of this effect at 8 and 9 1/2 years of age. We tested the hypothesis that PCB-related impulsive responding might be a function of impaired response inhibition. Children (n = 202) enrolled in the Oswego Children's Study were tested at 8 years of age using the NES2 Continuous Performance Test (CPT). This was followed by a series of Extended Continuous Performance Tests (E-CPT) at 9 1/2 years of age, designed to dissociate response inhibition from sustained attention. After taking into account more than 50 measured covariables, including maternal IQ, maternal sustained attention and maternal response inhibition, results revealed PCB-related associations with impulsive responding at both testing ages. At 8 years of age, prenatal PCB exposure was associated with increased impulsive responding on the CPT. At 9 1/2 years of age, E-CPT testing clearly indicated that the PCB-related impulsive responding was due to impaired response inhibition and not impaired sustained attention. These results were significant after extensive and rigorous control for multiple potential confounders, including several non-PCB contaminants (prenatal MeHg, DDE, HCB, and pre- and postnatal Pb). These data are consistent with, and in fact predicted by, several studies in PCB-exposed animals.
AB - We previously reported a relationship between prenatal PCB exposure and impulsive (excessive) responding on a continuous performance task in children at 4 1/2 years of age [P.W. Stewart, S. Fitzgerald, J. Reihman, B. Gump, E. Lonky, T. Darvill, J. Pagano, P. Hauser, Prenatal PCB exposure, the corpus callosum, and response inhibition, Environmental Health Perspectives 111 (13) (2003b) 1670-1677.]. The current study investigated the stability of this effect at 8 and 9 1/2 years of age. We tested the hypothesis that PCB-related impulsive responding might be a function of impaired response inhibition. Children (n = 202) enrolled in the Oswego Children's Study were tested at 8 years of age using the NES2 Continuous Performance Test (CPT). This was followed by a series of Extended Continuous Performance Tests (E-CPT) at 9 1/2 years of age, designed to dissociate response inhibition from sustained attention. After taking into account more than 50 measured covariables, including maternal IQ, maternal sustained attention and maternal response inhibition, results revealed PCB-related associations with impulsive responding at both testing ages. At 8 years of age, prenatal PCB exposure was associated with increased impulsive responding on the CPT. At 9 1/2 years of age, E-CPT testing clearly indicated that the PCB-related impulsive responding was due to impaired response inhibition and not impaired sustained attention. These results were significant after extensive and rigorous control for multiple potential confounders, including several non-PCB contaminants (prenatal MeHg, DDE, HCB, and pre- and postnatal Pb). These data are consistent with, and in fact predicted by, several studies in PCB-exposed animals.
KW - Continuous Performance Tests
KW - Impulsive responding
KW - Prenatal PCB exposure
KW - Response inhibition
UR - http://www.scopus.com/inward/record.url?scp=27844595855&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27844595855&partnerID=8YFLogxK
U2 - 10.1016/j.ntt.2005.07.003
DO - 10.1016/j.ntt.2005.07.003
M3 - Article
C2 - 16198536
AN - SCOPUS:27844595855
VL - 27
SP - 771
EP - 780
JO - Neurotoxicology and Teratology
JF - Neurotoxicology and Teratology
SN - 0892-0362
IS - 6
ER -