@article{a210c573c7bf4ab19befac960da0aa7a,
title = "Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene",
abstract = "The transformer (tra) gene regulates female somatic sexual differentiation and has no known function in males. It gives rise to two sizes of RNA, one non-sex-specific and one female-specific. These two RNAs are shown to be present throughout the life cycle, and related by the use of alternative first intron splice acceptor sites. The non-sex-specific RNA has a 73 base first intron, while that in the female-specific RNA is 248 bases. The non-sex-specific RNA has no long open reading frame, while the female-specific RNA has a single long open reading frame beginning at the first AUG. Substitution of a heat shock promoter for the tra promoter still leads to female-specific differentiation of otherwise tra- females. We suggest a mechanism by which Sex-lethal controls itself and tra.",
author = "Boggs, {Russell T.} and Paul Gregor and Suhair Idriss and Belote, {John M.} and Michael McKeown",
note = "Funding Information: We thank L. Kauvar, A. Cowman, and H. Steller for gifts of cDNA II-braries. and S. Poole for the pUChspUT-D plasmid. This work was supported by grants from the National Institutes of Health to M. M. and J. M. B. Parts of this work were supported by funds from the Rice and Mellon Foundations to the Salk Institute. M. M. is a Pew Scholar in the Biomedical Sciences. Parts of this work were carried out while P G. was a visiting graduate student on leave from the Department of Neurobiology, Welzmann Institute, 76100 Rehovot, Israel; P G. was supported in part by funds from the Friends of the Weizmann Institute In the U.S. R. T. B. was supported by an NIH postdoctoral training grant. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC. Section 1734 solely to indicate this fact.",
year = "1987",
month = aug,
day = "28",
doi = "10.1016/0092-8674(87)90332-1",
language = "English (US)",
volume = "50",
pages = "739--747",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "5",
}