Regulating cytoskeleton-based vesicle motility

Heidi Hehnly, Mark Stamnes

Research output: Contribution to journalShort survey

82 Scopus citations

Abstract

During vesicular transport, the assembly of the coat complexes and the selection of cargo proteins must be coordinated with the subsequent translocation of vesicles from the donor to an acceptor compartment. Here, we review recent progress toward uncovering the molecular mechanisms that connect transport vesicles to the protein machinery responsible for cytoskeleton-mediated motility. An emerging theme is that vesicle cargo proteins, either directly or through binding interactions with coat proteins, are able to influence cytoskeletal dynamics and motor protein function. Hence, a vesicle's cargo composition may help direct its intracellular motility and targeting.

Original languageEnglish (US)
Pages (from-to)2112-2118
Number of pages7
JournalFEBS Letters
Volume581
Issue number11
DOIs
StatePublished - May 22 2007
Externally publishedYes

Keywords

  • Actin
  • Dynein
  • Kinesin
  • Microtubules
  • Myosin
  • Vesicular transport

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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