Abstract
We report a novel trans-silylvinylation of internal alkynes catalyzed by RuHCl(CO)(PCy3)2. This method represents a highly regio- and stereoselective synthesis of functionalized dienes by means of an efficient tandem alkyne trans-silylruthenation, followed by an addition to acrylates. The products are further transformed by Pd-catalyzed cross couplings and carbonylations to afford dienes with significantly increased molecular complexity.
Original language | English (US) |
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Pages (from-to) | 1547-1551 |
Number of pages | 5 |
Journal | Chemical Science |
Volume | 4 |
Issue number | 4 |
DOIs | |
State | Published - Mar 4 2013 |
ASJC Scopus subject areas
- General Chemistry