Regio- and stereoselective trans-silylvinylation of internal alkynes catalyzed by RuHCl(CO)(PCy3)2

Jinbo Zhao, Shasha Liu, Nadia Marino, Daniel A. Clark

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

We report a novel trans-silylvinylation of internal alkynes catalyzed by RuHCl(CO)(PCy3)2. This method represents a highly regio- and stereoselective synthesis of functionalized dienes by means of an efficient tandem alkyne trans-silylruthenation, followed by an addition to acrylates. The products are further transformed by Pd-catalyzed cross couplings and carbonylations to afford dienes with significantly increased molecular complexity.

Original languageEnglish (US)
Pages (from-to)1547-1551
Number of pages5
JournalChemical Science
Volume4
Issue number4
DOIs
StatePublished - Mar 4 2013

ASJC Scopus subject areas

  • Chemistry(all)

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