We report a novel trans-silylvinylation of internal alkynes catalyzed by RuHCl(CO)(PCy3)2. This method represents a highly regio- and stereoselective synthesis of functionalized dienes by means of an efficient tandem alkyne trans-silylruthenation, followed by an addition to acrylates. The products are further transformed by Pd-catalyzed cross couplings and carbonylations to afford dienes with significantly increased molecular complexity.
|Original language||English (US)|
|Number of pages||5|
|State||Published - Mar 4 2013|
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