REDOX PROPERTIES OF BLEOMYCIN AND TALLYSOMYCIN AND A SERIES OF THEIR METALLODERIVATIVES.

James C. Dabrowiak, Frank S. Santillo

Research output: Contribution to journalArticle

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Abstract

D-c polarographic and cyclic voltammetric studies on bleomycin A//2 (BLM-A//2), tallysomycin A (TLM-A), a series of their metalloderivatives, and four of their components have been conducted. The antibiotics exhibit two reduction processes. The first, at minus 1. 22 V, has been assigned to the two electron reduction of the 4-amino pyrimidine moiety of the drugs. A second multielectron reduction process appears to be associated with the bithiazole portion of the antibiotics. The first polarographic wave, due to the pyrimidine moiety, is sensitive to metal binding phenomena. The binding of Fe(II), Co(II,III), Ni(II), and Zn(II) to the antibiotics, causes this wave to disappear from the polarogram of the metalloderivatives.

Original languageEnglish (US)
Pages (from-to)2091-2095
Number of pages5
JournalJournal of the Electrochemical Society
Volume126
Issue number12
StatePublished - Dec 1979

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ASJC Scopus subject areas

  • Electrochemistry
  • Surfaces, Coatings and Films
  • Surfaces and Interfaces

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