REDOX PROPERTIES OF BLEOMYCIN AND TALLYSOMYCIN AND A SERIES OF THEIR METALLODERIVATIVES.

James C. Dabrowiak, Frank S. Santillo

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

D-c polarographic and cyclic voltammetric studies on bleomycin A//2 (BLM-A//2), tallysomycin A (TLM-A), a series of their metalloderivatives, and four of their components have been conducted. The antibiotics exhibit two reduction processes. The first, at minus 1. 22 V, has been assigned to the two electron reduction of the 4-amino pyrimidine moiety of the drugs. A second multielectron reduction process appears to be associated with the bithiazole portion of the antibiotics. The first polarographic wave, due to the pyrimidine moiety, is sensitive to metal binding phenomena. The binding of Fe(II), Co(II,III), Ni(II), and Zn(II) to the antibiotics, causes this wave to disappear from the polarogram of the metalloderivatives.

Original languageEnglish (US)
Pages (from-to)2091-2095
Number of pages5
JournalJournal of the Electrochemical Society
Volume126
Issue number12
StatePublished - Dec 1979

Fingerprint

antibiotics
Bleomycin
Antibiotics
pyrimidines
Anti-Bacterial Agents
drugs
Metals
Electrons
causes
Pharmaceutical Preparations
metals
Oxidation-Reduction
talisomycin
electrons
pyrimidine

ASJC Scopus subject areas

  • Electrochemistry
  • Surfaces, Coatings and Films
  • Surfaces and Interfaces

Cite this

REDOX PROPERTIES OF BLEOMYCIN AND TALLYSOMYCIN AND A SERIES OF THEIR METALLODERIVATIVES. / Dabrowiak, James C.; Santillo, Frank S.

In: Journal of the Electrochemical Society, Vol. 126, No. 12, 12.1979, p. 2091-2095.

Research output: Contribution to journalArticle

Dabrowiak, James C. ; Santillo, Frank S. / REDOX PROPERTIES OF BLEOMYCIN AND TALLYSOMYCIN AND A SERIES OF THEIR METALLODERIVATIVES. In: Journal of the Electrochemical Society. 1979 ; Vol. 126, No. 12. pp. 2091-2095.
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