TY - JOUR
T1 - Recovery of the human compound action potential following prior stimulation
AU - Murnane, Owen D.
AU - Prieve, Beth A.
AU - Relkin, Evan M.
N1 - Funding Information:
We thank Dr. John Doucet for many helpful discussions and Dr. Richard Wilson for comments on early versions of the manuscript. In addition, we thank Dr. Rick Schmiedt and two anonymous reviewers for their helpful comments and criticisms. This work was supported by Research Grants DC00380 from the National Institute on Deafness and Other Communication Disorders, National Institutes of Health and IBN-9120262 from the National Science Foundation as well as the Syracuse University Graduate School.
PY - 1998/10
Y1 - 1998/10
N2 - The recovery from prior stimulation of the compound action potential (CAP) was measured using a forward masking stimulus paradigm in four normal- hearing, human subjects. The CAP was recorded using a wick electrode placed on the tympanic membrane. The effects of a 4000-Hz, 97-dB SPL conditioning stimulus on CAP amplitude in response to a 4000-Hz probe were measured as a function of conditioner-probe interval for three probe levels. The normalized probe response amplitude was completely recovered to the control values at an average conditioner-probe interval of 1359 ms, similar to that observed in chinchilla (Relkin, E.M., Doucet, J.R., Sterns, A., 1995. Recovery of the compound action potential following prior stimulation: evidence for a slow component that reflects recovery of low spontaneous-rate auditory neurons, Hear. Res. 83, 183-189). The present results are interpreted as a consequence of the slow recovery of low spontaneous-rate (SR), high threshold neurons from prior stimulation (Relkin, E.M., Doucet, J.R., 1991. Recovery from prior stimulation. I: Relationship to spontaneous firing rates of primary auditory neurons. Hear. Res. 55, 215-222) and may provide indirect physiological evidence for the existence of a class of low-SR auditory neurons in humans.
AB - The recovery from prior stimulation of the compound action potential (CAP) was measured using a forward masking stimulus paradigm in four normal- hearing, human subjects. The CAP was recorded using a wick electrode placed on the tympanic membrane. The effects of a 4000-Hz, 97-dB SPL conditioning stimulus on CAP amplitude in response to a 4000-Hz probe were measured as a function of conditioner-probe interval for three probe levels. The normalized probe response amplitude was completely recovered to the control values at an average conditioner-probe interval of 1359 ms, similar to that observed in chinchilla (Relkin, E.M., Doucet, J.R., Sterns, A., 1995. Recovery of the compound action potential following prior stimulation: evidence for a slow component that reflects recovery of low spontaneous-rate auditory neurons, Hear. Res. 83, 183-189). The present results are interpreted as a consequence of the slow recovery of low spontaneous-rate (SR), high threshold neurons from prior stimulation (Relkin, E.M., Doucet, J.R., 1991. Recovery from prior stimulation. I: Relationship to spontaneous firing rates of primary auditory neurons. Hear. Res. 55, 215-222) and may provide indirect physiological evidence for the existence of a class of low-SR auditory neurons in humans.
KW - Compound action potential
KW - Forward masking
KW - Human
KW - Recovery
KW - Spontaneous rate
UR - http://www.scopus.com/inward/record.url?scp=0031729586&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031729586&partnerID=8YFLogxK
U2 - 10.1016/S0378-5955(98)00136-1
DO - 10.1016/S0378-5955(98)00136-1
M3 - Article
C2 - 9822915
AN - SCOPUS:0031729586
SN - 0378-5955
VL - 124
SP - 182
EP - 189
JO - Hearing Research
JF - Hearing Research
IS - 1-2
ER -